摘要
沙棘为药食同源类中药,具有止咳化痰、健胃消食、活血散瘀等功效。沙棘除含有黄酮、酚类、蛋白质、维生素和氨基酸等成分,还有丰富的多糖类成分。为探究沙棘多糖的功能价值和研究现状,该研究通过查阅国内外文献系统梳理沙棘多糖的提取工艺、结构特征、药理作用与作用机制,结果发现沙棘多糖具有抗肿瘤、降血糖、抗氧化、免疫调节、改善肠道菌群、抗炎、抗高脂血症等功能。多糖提取工艺多样,涉及热水提取、微波提取、超声波提取、酶法提取、闪式提取法、超声波-微波协同提取、翠热水提取、酶法-超声波协同提取等,综合分析以热水提取适合产业开发应用。然而,目前已经从沙棘多糖中分离纯化得到多种均一多糖,但其药效、结构和构效关系还有待深入挖掘和研究。该研究可为沙棘多糖研究开发提供参考。
Hippophae rhamnoides is a traditional Chinese medicine with homology of medicine and food, which has the effects of relieving cough and resolving phlegm, strengthening the stomach and digestion, and promoting blood circulation and resolving blood stasis. H. rhamnoides contains not only flavonoids, phenols, proteins, vitamins, and amino acids but also abundant polysaccharides. In order to explore the functional value and current research status of H. rhamnoides polysaccharides, this study systematically summarized the extraction process, structural characteristics, pharmacological effects, and mechanism of action of H. rhamnoides polysaccharides by reviewing Chinese and foreign literature. The results showed that H. rhamnoides polysaccharides have anti-tumor, hypoglycemic, antioxidant, immune regulation, antiinflammatory, and anti-hyperlipidemia functions and could improve intestinal microbiota. There were various extraction processes for polysaccharides, including hot water extraction, microwave extraction, ultrasonic extraction, enzymatic extraction, flash extraction, ultrasonic-microwave synergistic extraction, emerald hot water extraction, enzymatic-ultrasonic synergistic extraction, etc. Based on comprehensive analysis, hot water extraction is suitable for industrial development and application. However, multiple homogeneous polysaccharides have been isolated and purified from H. rhamnoides polysaccharides, but their efficacy, structure, and structure-activity relationship still need to be further explored and studied. This study can provide a reference for the research and development of H. rhamnoides polysaccharides.
作者
赵飞亚
张铃声
陶爱恩
ZHAO Feiya;ZHANG Lingsheng;TAO Aien(Medical School,Lijiang Culture and Tourism College,Lijiang 674199,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2024年第11期290-298,共9页
Chinese Journal of Experimental Traditional Medical Formulae
基金
教育部哲学社会科学研究后期资助项目(21JHQ079)
云南省科技厅科技计划面上项目(202201AT070001)
云南省科技厅乡村振兴专项兴边富民项目(202104BM090017)
云南省民族文化保护与双百工程项目(2021MW01)
云南省教育厅科学研究基金项目(2022J1214)
云南省大学生创新创业训练计划项目(SC20201332804,SC20211332803,SC202213328004)
滇西北道地药材研究与开发创新团队校级培育项目(2021PT01)
丽江市科技计划项目(2022LJSHFZ010)
校级中青年学术和技术后备人才支持项目(2022xshb05)。
关键词
沙棘多糖
提取工艺
化学结构
抗肿瘤
降血糖
抗氧化
免疫调节
改善肠道菌群
抗炎
Hippophae rhamnoides polysaccharides
extraction process
chemical structure
antitumor
hypoglycemic
antioxidant
immune regulation
i
mprovement of intestinal microbiota
antiinflammatory
