摘要
目的评估清胰汤联合乌司他丁对急性胰腺炎患者肠道功能恢复及炎性因子水平的影响。方法选取2020年5月至2023年5月于太和县人民医院就诊的111例急性胰腺炎患者,最终纳入90例急性胰腺炎患者作为研究对象。采用随机字母表分为对照组(n=45)和观察组(n=45)。两组均进行常规治疗,对照组行乌司他丁治疗,观察组在对照组的基础上加用清胰汤治疗。观察比较两组患者的中医症候评分、临床疗效、肠道功能恢复情况(肠鸣音恢复时间、首次排气时间、首次排便时间)、炎性因子水平(TNF-α、IL-1β、IL-6、PAF、MCP-1)及不良反应。结果治疗后,观察组患者的总有效率为95.56%,显著高于对照组的77.78%(P<0.05)。两组患者的胸闷腹痛、身热口渴、恶心呕吐、头身沉重、便溏不爽等中医证候评分均较治疗前降低,且观察组各项评分均显著低于对照组(P<0.05)。观察组患者的肠道功能恢复时间短于对照组(P<0.05)。两组患者炎性因子水平均较治疗前显著降低,且观察组炎性因子水平均显著低于对照组(P<0.01)。观察组不良反应发生率显著低于对照组(P<0.05)。结论清胰汤联合乌司他丁较乌司他丁治疗急性胰腺炎的临床疗效更显著,能进一步缩短肠道功能恢复时间、缓解炎症、降低不良反应发生率。
Objective To evaluate the effects of Qingyi decoction combined with ulinastatin on the recovery of intestinal function and the levels of inflammatory factors in patients with acute pancreatitis.Methods From May 2020 to May 2023,111 patients with acute pancreatitis who visited Taihe County People's Hospital were selected,and 90 patients with acute pancreatitis were finally included as the study objects.Using a random alphabetical list,patients were divided into a control group(n=45)and an observation group(n=45).Both groups underwent conventional treatment,the control group received ulinastatin,while the observation group was treated with Qingyi decoction in addition to ulinastatin.Traditional Chinese Medicine symptom scores,clinical efficacy,recovery of intestinal function(time to return of bowel sounds,time to first flatus,time to first stool),levels of inflammatory factors(TNF-α,IL-1β,IL-6,PAF,MCP-1),and adverse reactions were compared between the two groups.Results After treatment,the total effective rate in the observation group was 95.56%,significantly higher than the 77.78%in the control group(P<0.05).Symptom scores for chest tightness,abdominal pain,body heat,thirst,nausea,vomiting,heaviness of the head and body,and unsatisfactory defecation,which are evaluated based on Traditional Chinese Medicine criteria,decreased in both groups after treatment.Moreover,scores in the observation group were notably lower than those in the control group(P<0.05).The recovery of intestinal function in the observation group was significantly superior to the control group(P<0.05).Both groups demonstrated a marked decrease in inflammatory factors post-treatment,and the levels in the observation group were significantly lower than those in the control group(P<0.01).The incidence of adverse reactions in the observation group was significantly lower than that in control group(P<0.05).Conclusion The clinical effect of Qingyi decoction and ulinastatin is more significant than that of ulinastatin alone in the treatment of acute pancreatitis.It can further shorten the time for intestinal function recovery,alleviate inflammation,and reduce the incidence of adverse reactions.
作者
徐清华
张振林
李浩
Xu Qinghua;Zhang Zhenlin;Li Hao(Departmet of Internal medicine of TCM,Taihe County People's Hospital,Taihe Hospital Affiliated to Wannan Medical College,Fuyang 236600,China)
出处
《中华消化病与影像杂志（电子版）》
2024年第3期253-257,共5页
Chinese Journal of Digestion and Medical Imageology(Electronic Edition)
关键词
急性胰腺炎
清胰汤
乌司他丁
临床疗效
肠道功能
炎性因子
Acute pancreatitis
Qingyi decoction
Ulinastatin
Clinical efficacy
Intestinal function
Inflammatory factors
