摘要
在促进剂K_(2)CO_(3)/TiO_(2)的作用下,通过二氧化碳的羧基化反应成功地将噻吩转化为2-噻吩甲酸,并优化了合成条件,考察了促进剂K_(2)CO_(3)/TiO_(2)的结构、性质对合成路线的影响。结果表明,K_(2)CO_(3)/TiO_(2)起主要促进作用的为表面无定型K_(2)CO_(3);考虑到产物的热稳定性,反应温度不宜超过300℃;产物在反应刚开始的1 h内大量生成,此后生成速率急速下降。该研究不仅开发了新颖、环保和高效的2-噻吩甲酸合成路线,还拓展了二氧化碳的高效利用途径。
Under the promotion of K_(2)CO_(3)/TiO_(2),thiophene is successfully converted to 2-thiophenic acid by carboxylation of carbon dioxide.The synthesis conditions are optimized,and the influences of the structure and properties of K_(2)CO_(3)/TiO_(2)promoter on the synthesis route are evaluated.The results show that the amorphous K_(2)CO_(3)on the surface of K_(2)CO_(3)/TiO_(2)plays the major promotion role.Considering the thermal stability of the product,the reaction temperature should not exceed 300℃.The product is generated in large quantity within 1 hour at the beginning of the reaction,and the generation rate rapidly decreases thereafter.This study develops a novel,environmentally friendly,and efficient synthesis route for 2-thiophenic acid,and also expands the efficient utilization pathways for carbon dioxide.
作者
姜维佳
雷伟
陈杰
王青
王玉高
JIANG Wei-jia;LEI Wei;CHEN Jie;WANG Qing;WANG Yu-gao(Neurobiology Research Center,Shanxi University of Chinese Medicine,Jinzhong 030619,China;College of Chemical Engineering and Technology,Taiyuan University of Technology,Taiyuan 030024,China;PetroChina Changqing Oilfield(Yulin)Oil and Gas Co.,Ltd.,Yulin 719000,China)
出处
《现代化工》
CAS
CSCD
北大核心
2024年第6期175-180,共6页
Modern Chemical Industry
基金
山西中医药大学中西医结合基础学科2022年度开放课题(2022-XK-003)
山西省基础研究计划资助项目(202203021221069)。
关键词
2-噻吩甲酸
抗癌药中间体
二氧化碳
羧基化
合成
2-thiophenic acid
anticancer drug intermediate
carbon dioxide
carboxylation
synthesis
