摘要
目的探讨对高危妊娠产后出血患者采用卡前列素氨丁三醇注射液+缩宫素注射液完成治疗后获得的临床效果。方法选取兖州区人民医院于2021年2月—2023年4月收治的80例高危妊娠产后出血患者为研究对象,以投掷硬币法分为两组,各40例。参照组采用缩宫素注射液治疗,研究组采用卡前列素氨丁三醇注射液+缩宫素注射液治疗。比较两组产后2、24 h出血量、不良反应总发生率、凝血指标水平。结果研究组产后2、24 h出血量少于参照组,差异有统计学意义(P均<0.05)。研究组不良反应(低热、恶心呕吐以及血压升高)总发生率(7.50%)低于参照组(27.50%),差异有统计学意义(χ^(2)=5.541,P<0.05)。治疗前,两组血浆凝血酶原时间(Prothrombin Time,PT)、部分活化凝血活酶时间(Activated Partial Thromboplastin Time,APTT)、D-二聚体(D-dimer,D-D)以及纤维蛋白原(Fibrinogen,Fbg)水平比较,差异无统计学意义(P均>0.05);治疗后,研究组PT、APTT、D-D以及Fbg水平优于参照组,差异有统计学意义(P均<0.05)。结论临床对高危妊娠产后出血患者采用卡前列素氨丁三醇注射液+缩宫素注射液治疗,可显著减少患者产后2、24 h出血量,降低不良反应发生率,有效改善凝血指标水平。
Objective To explore the clinical effect of carprost triol injection+oxytocin injection in high-risk pregnancy postpartum hemorrhage patients.Methods A total of 80 patients with postpartum hemorrhage during high-risk pregnancy admitted to Yanzhou District People′s Hospital from February 2021 to April 2023 were selected as the study objects and divided into two groups with 40 cases each by coin throwing method.The reference group was treated with oxytocin injection,and the study group was treated with caprost triol injection+oxytocin injection.The blood loss at 2 h and 24 h after delivery,the total incidence of adverse reactions and the level of coagulation index were compared between the two groups.Results The postpartum blood loss at 2 h and 24 h in the study group were less than those in the reference group,and the differences were statistically significant(both P<0.05).The total incidence of adverse reactions(hypothermia,nausea,vomiting and hypertension)in the study group(7.50%)was lower than that in the reference group(27.50%),and the difference was statistically significant(χ^(2)=5.541,P<0.05).Before treatment,there was no statistically significant difference in the levels of prothrombin time(PT),activated partial thromboplastin time(APTT),D-dimer(D-D),and fibrinogen(Fbg)between the two groups(all P>0.05).After treatment,the levels of PT,APTT,D-D and Fbg in the study group were better than those in the reference group,and the differences were statistically significant(all P<0.05).Conclusion Clinical treatment with carprost triol injection+oxytocin injection for patients with postpartum hemorrhage in high-risk pregnancies can significantly reduce the amount of postpartum blood loss at 2 h and 24 h,reduce the incidence of adverse reactions,and effectively improve the level of coagulation indicators.
作者
王加青
李琳
WANG Jiaqing;LI Lin(Department of Obstetrics,Yanzhou District People′s Hospital,Jining,Shandong Province,272100 China)
出处
《系统医学》
2024年第8期169-172,共4页
Systems Medicine
关键词
卡前列素氨丁三醇注射液
缩宫素注射液
高危妊娠产后出血
产后出血量
不良反应
凝血指标
Carprost triol injection
Oxytocin injection
Postpartum hemorrhage of high-risk pregnancy
Postpartum blood loss
Adverse reactions
Coagulation index
