摘要
利用浸涂法制备了沉积聚苯乙烯-二乙烯基苯(PS-DVB)颗粒的PDMS薄膜,通过优化萃取条件,建立基于自制固相微萃取薄膜的电子烟中低沸点香精和高沸点违禁药物的顶空气相色谱-质谱分析方法,确定最佳萃取温度和萃取时间分别为180℃和30 min。对比了热脱附与液液萃取两种薄膜脱附方式,结果显示二者在分析电子烟香精和违禁药物方面相互补充,但考虑方法的适用性,建立了基于液液萃取脱附方式的电子烟特征成分检验技术。通过与传统的样品处理方式直接稀释进样和商品化固相微萃取纤维对比,凸显基于自制PS-DVB/PDMS薄膜顶空分析电子烟特征成分的灵敏度与普适性,所建方法具有去除丙二醇和丙三醇基质干扰、满足高温萃取需求、吸附容量大、成本低的优势。将所建方法应用于实际案件中电子烟样品的检测,检测结果与案情相符,证实方法的准确性与实用性。该研究为电子烟液顶空气体中的香精和违禁药物提供了一种高效、准确的微全分析方案,对生命健康、法庭科学和和公共环境领域具有重要意义。
Electronic cigarettes(e-cigarettes)are popular nicotine delivery devices.e-cigarette liquid is a complex mixture of ingredients with a viscous base,in addition to the propylene glycol(PG),vegetable glycerin(VG)and fla⁃vorings,illicit drugs are often added.Testing for glamorous flavors and illicit drugs in e-cigarettes is a common re⁃quest from health surveillance,forensic science and market regulation.In this work,we have combined thin-film solid-phase microextraction with a simple gas chromatography-mass spectrometry method.The established method re⁃alized the micro-total analysis of low-boiling-point flavors and high-boiling-point illicit drugs in headspace of ecigarettes.A polystyrene-divinylbenzene particle-loaded membrane was prepared by coating.The sampling conditions of flavors and illicit drugs were optimized,and the optimal extraction condition was 30 min at 180℃.All the composi⁃tions in the headspace of e-cigarettes showed acceptable accuracy.Thermal desorption experiments of membranes were further explored and the results obtained complemented with solvent extraction desorption.However,consider⁃ing the real case handling situation,solvent extraction was chosed as desorption method for establishing the ecigarette analytical methods.At the same time,thermal desorption method enriches the selection space for handling e-cigarette related samples.Compared with conventional direct dilution injection and commercial solid-phase microex⁃traction fibers,this method enhances the analytical sensitivity by expanding the adsorption capacity,improving the universality by removing VG and PG.In addition,it is suitable for high-temperature extraction and has the advantage of low cost.Lastly,the proposed method was applied to three seized e-cigarette which results were consistent with the case intelligence,verifying the accuracy of this method.This work provides an efficient and accurate micro-total ana⁃lytical protocol for flavors and illicit drugs in headspace of e-cigarette,which is important for health,forensic science and the public environment.
作者
牛可歆
赵霞
聂洪港
廉洁
李冬梅
袁育航
王绘超
李艋
NIU Ke-xin;ZHAO Xia;NIE Hong-gang;LIAN Jie;LI Dong-mei;YUAN Yu-hang;WANG Hui-chao;LI Meng(School of Investigation,People’s Public Security University of China,Beijing 100038,China;Beijing Branch of National Drug Laboratory,Beijing 100164,China;Analytical Instrumentation Center,Peking University,Beijing 100871,China)
出处
《分析测试学报》
CAS
CSCD
北大核心
2024年第6期848-857,共10页
Journal of Instrumental Analysis
基金
Fundamental Research Funds for the Central Universities(2022JKF02006)
Open Project of Key Laboratory of Drug Monitoring and Control,Ministry of Public Security(2023-KLDMC-02)。
