摘要
目的探讨糖类抗原125(CA125)、血管生成素-2(Ang-2)在子宫肌瘤患者血清中的表达及其与术后转归的关系,为评估肿瘤活性和预测术后复发风险提供参考。方法选取2019年1月至2020年12月攀枝花市第二人民医院收治的60例接受子宫肌瘤剔除术的患者作为研究对象,设为观察组。另选取同期60例健康体检子宫正常者设为对照组。检测对照组及观察组术前、术后7 d血清CA125、Ang-2水平,并对观察组进行1年的随访。采用Logistic回归分析影响术后复发的危险因素;采用受试者工作特征(ROC)曲线分析血清CA125、Ang-2水平与术后子宫肌瘤复发的预测价值。结果观察组术前血清CA125、Ang-2水平均高于对照组(P<0.05),观察组术后7 d血清CA125、Ang-2水平均低于观察组术前(P<0.05)。观察组术后随访1年,其中复发15例,未复发45例,复发率为25.0%。复发组术后7 d血清CA125、Ang-2水平均高于未复发组(P<0.05)。Logistic回归分析显示,术后7 d血清CA125、Ang-2水平是影响术后复发的独立危险因素(OR=1.032、1.046,P<0.05)。ROC曲线分析显示,术后7 d血清CA125、Ang-2水平对术后肌瘤复发的预测价值较高,曲线下面积分别为0.823、0.841。结论子宫肌瘤患者血清CA125、Ang-2水平高与子宫肿瘤生长及复发有关,可作为评估子宫肌瘤活性和预测术后转归的指标,是影响术后复发的独立危险因素,具有较高的预测价值。
Objective To explore the serum expressions of carbohydrate antigen 125(CA125)and angiopoietin-2(Ang-2)in patients with uterinefibroids and their relationship with postoperative outcomes,in order to provide reference for evaluating tumor activity and predicting postoperative recurrence risk.Methods A total of 60 patients who underwent uterine fibroid removal surgery admitted to the Second People′s Hospital of Panzhihua from January 2019 to December 2020 were selected as the study subjects,and set as the observation group.Another 60 healthy individuals underwent physical examination with normal uterus during the same period were selected as the control group.The serum levels of CA125 and Ang-2 in the control group and observation group before and 7 days after surgery were detected,and the observation group were followed up for 1 year.Logistic regression analysis were used to analyze risk factors influencing postoperative recurrence.The predictive value of serum CA125,Ang-2 levels and postoperative uterine fibroid recurrence was analyzed using receiver operating characteristic(ROC)curves.Results The preoperative serum levels of CA125 and Ang-2 in the observation group were higher than those in the control group(P<0.05),while the serum levels of CA125 and Ang-2 in the observation group were lower than those in the observation group 7 days after surgery(P<0.05).The observation group was followed up for 1 year after surgery,with 15 cases experiencing recurrence and 45 cases not experiencing recurrence,with a recurrence rate of 25.0%.The serum CA125 and Ang-2 levels in the recurrent group were higher than those in the non-recurrent group 7 days after surgery(P<0.05).Logistic regression analysis showed that serum CA125 and Ang-2 levels at 7 days after surgery were independent risk factors for postoperative recurrence(OR=1.032,1.046;P<0.05).ROC curve analysis showed that serum CA125 and Ang-2 levels at 7 days after surgery had a high predictive value for postoperative fibroids recurrence,with areas under curves of 0.823 and 0.841,respectively.Conclusions The high levels of serum CA125 and Ang-2 in patients with uterine fibroids are related to the growth and recurrence of uterine tumors,and can be used as indicators to evaluate uterine fibroid activity and predict postoperative outcomes.They are independent risk factors affecting postoperative recurrence and have high predictive value.
作者
陈俊
程静
袁应美
王琦
冷开玉
CHEN Jun;CHENG Jing;YUAN Yingmei;WANG Qi;LENG Kaiyu(Department of Obstetrics and Gynecology,the Second People′s Hospital of Panzhihua,Panzhihua 617005,Sichuan,China)
出处
《中国性科学》
2024年第5期78-82,共5页
Chinese Journal of Human Sexuality
