摘要
手足口病(hand, foot and mouth disease, HFMD)是一种可由多种肠道病毒引起的以儿童急性感染为主的全球性传染病。近期,柯萨奇病毒A组6型(coxsackievirus A6,CVA6)引起的典型及非典型HFMD在多个国家及地区发病率明显上升且临床表现多样。而CVA6的分子进化、人群群体免疫屏障的建立等均可影响HFMD的暴发流行及病原谱的变迁。现就CVA6的流行、分子进化与重组、氨基酸变异、结构解析及血清流行病学研究作一概述,旨在为HFMD的防控提供思路。
Hand, foot and mouth disease(HFMD) is a global infectious disease caused by a variety of enteroviruses, which mainly infects children. Recently, the incidence of typical and atypical HFMD caused by coxsackievirus A6(CVA6) has increased significantly in many countries and regions with diverse clinical manifestations. The molecular evolution of CVA6 and the establishment of herd immunity barrier can affect the outbreak and change of pathogen spectrum of HFMD. In this review, the epidemiology, molecular evolution and recombination, amino acid variation, structural analysis and seroepidemiology of CVA6 are reviewed, aiming to provide ideas for the prevention and control of HFMD.
作者
韦欢欢(综述)
朱俊萍(审校)
WEI Huanhuan;ZHU Junping(National Experimental Teaching Demonstration Center of Basic Medicine,School of Basic Medicine Science,Capital Medical University,Bejing 100069,China;Department of Medical Laboratory,the Second Affiliated Hospital of Guangxi Medical University,Nanning 530005,Guangxi Zhuang Autonomous Region,China;不详)
出处
《微生物学免疫学进展》
CAS
2024年第1期72-78,共7页
Progress In Microbiology and Immunology
关键词
手足口病
柯萨奇病毒A组6型
临床症状
分子进化
基因重组
结构解析
氨基酸变异
血清流行病学
Hand,foot and mouth disease
Coxsackievirus A6(CVA6)
Clinical symptoms
Molecular evolution
Recombina-tion
Structure analysis
Amino acid variation
Seroepidemiology
