摘要
目的对比卵泡期长方案与黄体期长方案在不同年龄卵巢储备功能正常助孕人群中的临床应用效果。方法回顾性分析2018年1月至2021年12月在遵义医科大学附属医院生殖医学科行IVF-ET/ICSI助孕治疗患者的临床资料,按照纳入排除标准选取1196例助孕患者临床资料,根据促排卵方案不同分为卵泡期长方案组934例和黄体期长方案组262例;根据年龄不同分为<35岁组与35~40岁组。观察比较两种促排卵方案在不同年龄组的一般资料、促排卵指标、实验室指标及临床结局。结果①年龄<35岁组:卵泡期长方案组的Gn总量、Gn天数、临床妊娠率、卵裂期临床妊娠率、累积妊娠率均高于黄体期长方案组,差异有统计学意义(P<0.05)。②年龄35~40岁组:卵泡期长方案组的Gn总量、Gn天数、hCG阳性率、临床妊娠率、卵裂期临床妊娠率、累积妊娠率均高于黄体期长方案组,差异有统计学意义(P<0.05)。结论在卵巢储备功能正常的不同年龄助孕人群中,虽然卵泡期长方案比黄体期长方案使用Gn总量及天数增加,但能显著提高临床妊娠率、卵裂期临床妊娠率和累积妊娠率,获得更好的临床疗效。
Objective The clinical application effects of long follicular phase protocol and long luteal phase protocol in different age groups with normal ovarian reserve function were compared.Methods Retrospective analysis of the clinical data of patients undergoing IVF-ET/ICSI in the Department of Reproductive Medicine,Affiliated Hospital of Zunyi Medical University from January 2018 to December 2021.The clinical data of 1196 assisted pregnancy patients were selected according to the inclusion and exclusion criteria.According to the different ovulation induction protocol,they were divided into 934 cases in the follicular phase long protocol group and 262 cases in the luteal phase long protocol group.According to the age,they were divided into<35 years old group and 35~40 years old group.The general data,ovulation induction indexes,laboratory indexes and clinical outcomes of the two ovulation induction protocol in different age groups were observed.Results①Age<35 years old group:The total amount of Gn,Gn days,clinical pregnancy rate,cleavage clinical pregnancy rate and cumulative pregnancy rate in the follicular phase long protocol group were higher than those in the luteal phase long protocol group,and the difference was statistically significant(P<0.05).②Age 35~40 years old group:The total amount of Gn,Gn days,positive rate of hCG,clinical pregnancy rate,cleavage stage clinical pregnancy rate and cumulative pregnancy rate in the follicular phase long protocol group were higher than those in the luteal phase long protocol group,and the difference was statistically significant(P<0.05).Conclusion In the different age groups with normal ovarian reserve function,the total amount and days of Gn used in the long follicular phase protocol were higher than those in the long luteal phase protocol,but it could significantly improve the clinical pregnancy rate,cleavage clinical pregnancy rate and cumulative pregnancy rate,and obtain better clinical efficacy.
作者
吴述钰
王德婧
Wu Shuyu;Wang Dejing(Department of Reproductive Medicine,Affiliated Hospital of Zunyi Medical University,Department of Obstetrics and Gynecology,Affiliated Hospital of Zunyi Medical University,Zunyi Guizhou 563000,P.R.China)
出处
《中国计划生育和妇产科》
2024年第5期56-60,共5页
Chinese Journal of Family Planning & Gynecotokology
基金
贵州省科技厅科技成果应用与产业化项目(项目编号:20194447)。
关键词
卵泡期长方案
黄体期长方案
卵巢储备正常
累积妊娠率
临床疗效
long follicular phase protocol
long luteal phase protocol
normal ovarian reserve
cumulative pregnancy rate
clinical efficacy
