摘要
目的分析针对急性心肌梗死合并心功能不全经皮冠状动脉介入(Percutaneous Coronary Intervention,PCI)术患者应用沙库巴曲缬沙坦治疗的临床价值。方法选取2020年6月—2023年6月滨州市人民医院收治的106例急性心肌梗死合并心功能不全PCI术患者作为研究对象,根据治疗方案的不同分为参比组(n=53,行常规PCI围术期治疗)与研究组(n=53,在参比组的治疗基础上使用沙库巴曲缬沙坦)。比较两组心功能指标、心肌损伤指标。结果治疗后,研究组左心室射血分数、每搏量高于参比组,左心室舒张末期内径低于参比组,差异有统计学意义(P均<0.05)。治疗后,研究组血清超敏肌钙蛋白Ⅰ水平(0.07±0.02)ng/mL、N末端B型脑钠肽前体水平(1804.71±228.09)pg/mL低于参比组,差异有统计学意义(t=11.395、7.754,P均<0.001)。结论在急性心肌梗死合并心功能不全PCI术患者的治疗中,沙库巴曲缬沙坦的治疗效果显著,可促进患者功能指标、心肌损伤指标的改善。
Objective To analyze the clinical value of sacubactril valsartan in the treatment of acute myocardial infarction with cardiac insufficiency and percutaneous coronary intervention(PCI).Methods 106 patients with acute myocardial infarction combined with cardiac insufficiency PCI admitted to Binzhou People's Hospital from June 2020 to June 2023 were selected as the study subjects.According to different treatment plans,they were divided into the control group(n=53,receiving perioperative PCI treatment)and the study group(n=53,receiving sacubactril valsartan on the basis of the control group's treatment).The indexes of cardiac function and myocardial injury of two groups were compared.Results After treatment,the left ventricular ejection fraction,stroke volume in the study group were higher than those in the control group,while the left ventricular end diastolic diameter was lower than that in the control group,and the differences were statistically significant(all P<0.05).After treatment,the serum levels of hypersensitive troponinⅠ(0.07±0.02)ng/mL and N-terminal B-type brain natriuretic peptide precursor(1804.71±228.09)pg/mL in the study group were lower than those in the control group,and the differences were statistically significant(t=11.395,7.754,both P<0.001).Conclusion In the treatment of patients with acute myocardial infarction complicated by PCI,sacubactril valsartan has a significant therapeutic effect,which can promote the improvement of patients'functional indexes and myocardial injury indexes.
作者
刘国强
赵艳玲
贾欣欣
LIU Guoqiang;ZHAO Yanling;JIA Xinxin(Department of Emergency,Binzhou People's Hospital,Binzhou,Shandong Province,256600 China;Department of Inpatient Ward,Binzhou Bincheng District Yangliuxue Town Health Center,Binzhou,Shandong Province,256655 China)
出处
《系统医学》
2024年第9期49-51,60,共4页
Systems Medicine
关键词
急性心肌梗死
心功能不全
经皮冠状动脉介入术
沙库巴曲缬沙坦
Acute myocardial infarction
Cardiac insufficiency
Percutaneous coronary intervention
Sacubactril valsartan
