摘要
慢性肾脏病(chronic kidney disease,CKD)起病隐匿,因其发病率高、知晓率低、诊断率低、预后差和医疗费用高等特点,已成为危害人类健康的重要公共卫生问题。目前已有多项研究表明CKD在其发生发展过程中会出现不同程度的铁死亡特征,而中药可以通过靶向铁代谢、脂质过氧化及抗氧化系统等抑制铁死亡来延缓CKD的进展,铁死亡干预机制逐渐成为CKD研究的重点领域之一。中医药宝库集数千年传统中医经验与智慧于一身,注重人体功能的整体调节,能够激发人体的抗病和康复能力,对治疗CKD具有一定优势,但目前尚缺乏中医药干预铁死亡治疗CKD及铁死亡与CKD发病机制的总结性综述。该文汇总国内外最新研究进展,简述铁死亡主要的作用机制,对铁死亡与CKD发病机制的最新研究进展进行了系统综述,融合了与CKD铁死亡相关的“虚”“瘀”“痰浊”“毒”等中医理论,总结了中药活性成分、中药复方干预铁死亡治疗CKD的研究现状,以期从铁死亡角度为中医药防治CKD提供新靶点和新方向。
Chronic kidney disease(CKD) is an insidious disease that has become a significant global public health issue due to its high incidence rate,low awareness,low diagnostic rate,poor prognosis,and high medical costs.Recent studies have shown that CKD development is associated with varying degrees of ferroptosis features.Traditional Chinese medicine(TCM) can regulate iron metabolism,lipid peroxidation,antioxidant systems to inhibit ferroptosis and delay the progression of CKD.Consequently,the intervention mechanism of ferroptosis has become one of the focuses of CKD research.TCM has thousands of years of traditional experience and wisdom.It focuses on the overall regulation of human body functions and can stimulate the body′s disease resistance and recovery capabilities,which has certain advantages in treating CKD.However,there is currently a lack of comprehensive articles on the application of TCM in intervening ferroptosis to treat CKD and the pathogenesis of ferroptosis in CKD.Therefore,this article summarizes the latest research progress both domestically and internationally,briefly introduces the main mechanisms of ferroptosis,and systematically reviews the relationship between ferroptosis and CKD.The article integrates TCM theories related to ferroptosis in CKD,including "deficiency" "stasis" "phlegm turbidity" and "toxins" and summarizes the research status of active ingredients and herbal formulas in intervening ferroptosis to treat CKD.By considering ferroptosis from a new perspective,this article aims to provide new targets and directions for the application of TCM in treating CKD.
作者
杨璧英
刘相
胡爽
彭亚军
张伟宁
刘丙龙
何泽云
YANG Bi-ying;LIU Xiang;HU Shuang;PENG Ya-jun;ZHANG Wei-ning;LIU Bing-long;HE Ze-yun(the First Hospital of Hunan University of Chinese Medicine,Changsha 410021,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2024年第10期2629-2639,共11页
China Journal of Chinese Materia Medica
基金
湖南省卫生健康委卫生科研课题(W20243266)
湖南省自然科学基金项目(2023JJ30473)
湖南省自然科学基金面上项目(2021JJ30522)
湖南省中医重点专科项目(czxm-sbk-2023001)
刘良院士工作站——湖南省中西医结合肾病研究中心项目。
关键词
铁死亡
慢性肾脏病
铁代谢
脂质过氧化
抗氧化系统
中药活性成分
中药复方
ferroptosis
chronic kidney disease
iron metabolism
lipid peroxidation
antioxidant system
active ingredients in tra-ditional Chinese medicine
Chinese herbal formulas
