摘要
肠道微生物菌群参与了抑郁症的可能发生机制,其作为客观存在的影响肠与脑之间信息交流的物质基础,发挥着不可忽视的重要作用。肠脑之间存在双向应答的互动机制。抑郁症的发生不仅为患者带来了困扰,更为其家庭及社会带来了沉重的负担,这便使得临床医者在不断深入寻求治疗抑郁症的方法。在西医药优化抗抑郁药物作用的同时,中医药治疗抑郁症的优势也不断凸显,中医药疗效显著,且不良反应小,已成为人们更加愿意选择和接受的治疗方式。“五脏致郁”学说一直是中医界所遵从的治疗郁症的准则与方向,心、肝、脾、肺、肾无论何脏不及或过极均会引发情志的不适,诱发抑郁症的发生。近年来,随着“微生物-肠-脑轴”理论的不断发展与完善,越来越多的中医学者发现从调节胃肠功能的角度来治疗抑郁症,疗效显著且持久。文章通过对“微生物-肠-脑轴”的研究进展进行概述,总结了近年来中医界从调节胃肠功能的角度对郁症的认识及治疗概况,中医药可以通过调节脑肠肽的分泌及调节肠道微生物菌群而影响抑郁情绪。从临床使用的抗抑郁中药制剂来看,调节肠道菌群已成为中医药治疗抑郁症的新靶点。结合现代科学方法与研究成果,“微生物-肠-脑轴”理论为探索中医药治疗抑郁症提供了更广阔的思路。
Intestinal microbiota is involved in the possible mechanism of depression,which plays an important role as an objective material basis affecting the information exchange between the gut and the brain.There is an interactive mechanism of bidirectional response between the gut and the brain.The occurrence of depression not only brings trouble to patients,but also poses heavy burden to the family and society,which makes clinicians continue to seek ways to treat depression.While Western medicine is optimizing the effect of antidepressant drugs,the advantages of traditional Chinese medicine in the treatment of depression have also been highlighted,which is with significant efficacy and few adverse reactions,and it has become a treatment that people are more willing to choose and accept.The theory of“five viscera causing depression”has always been the guideline and direction for the treatment of depression in traditional Chinese medicine.The excessive or the deficiency of the heart,liver,spleen,lung and kidney will cause emotional discomfort and induce depression.In recent years,with the continuous development and improvement of the theory of“Microbiome-gut-brain axis”,more and more traditional Chinese medicine scholars have found that the treatment of depression from the perspective of regulating gastrointestinal function has a significant and lasting effect.The paper summarizes the research progress of“Microbiome-gut-brain axis”and summarizes the understanding and treatment of depression from the perspective of regulating gastrointestinal function in traditional Chinese medicine in recent years.Traditional Chinese medicine can affect depression by regulating the secretion of brain gut peptide and regulating intestinal microbiota.From the perspective of traditional Chinese medicine preparations used in clinical antidepressants,regulating intestinal flora has become a new target of traditional Chinese medicine in treating depression.Combined with modern scientific methods and research results,the theory of“Microbiome-gut-brain axis”provides a broader idea for exploring the treatment of depression in traditional Chinese medicine.
作者
姜浩
赵杰
王铁云
JIANG Hao;ZHAO Jie;WANG Tieyun
出处
《中医临床研究》
2024年第9期135-138,共4页
Clinical Journal Of Chinese Medicine
关键词
抑郁症
微生物-肠-脑轴
中医药
Depression
Microbiome-gut-brain axis
Traditional Chinese medicine
