摘要
目的探究牙周引导组织再生术(GTR)联合正畸治疗在错[牙合]畸形伴牙周病患者中的效果。方法选取90例错[牙合]畸形伴牙周病患者,根据信封法分为常规组和GTR组各45例,常规组给予牙周基础治疗和正畸治疗,GTR组在常规组基础上联合GTR治疗。比较两组治疗效果、牙周指标、牙龈炎症指标、生活质量及安全性指标。结果治疗后,GTR组治疗总有效率为95.56%(43/45),高于常规组的82.22%(37/45),两组比较差异有统计学意义(P<0.05);治疗后,两组牙龈指数(GI)、龈沟出血指数(SBI)均降低,且GTR组低于常规组(P均<0.05);治疗后,两组白细胞介素-6(IL-6)、基质金属蛋白酶-8(MMP-8)、C反应蛋白(CRP)均降低,且GTR组低于常规组(P均<0.05);治疗后,两组口腔健康相关生活质量量表评分均降低,且GTR组低于常规组(P<0.05);GTR组不良反应发生率为4.44%(2/45),低于常规组的20.00%(9/45),两组比较差异有统计学意义(P<0.05)。结论GTR联合正畸治疗用于错畸形伴牙周病患者效果较好,能改善患者牙周健康状态、抑制患者牙周炎症反应、提升患者生活质量、降低患者术后不良反应。
Objective To explore the efficacy of periodontal-guided tissue regeneration(GTR)combined with orth-odontic treatment for patients with malocclusion and periodontal disease.Methods Ninety patients with malocclusion and periodontal disease were selected.According to the envelope method,they were divided into the conventional group and the GTR group,with 45 cases in each group.Patients in the conventional group received periodontal basic treatment and orthodontic treatment,and patients in the GTR group received GTR treatment based on the conventional group.The therapeutic effect,periodontal index,gingival inflammation index,quality of life and safety index were compared between the two groups.Results After treatment,the total effective rate in the GTR group was 95.56%(43/45),which was higher than that[82.22%(37/45)]in the conventional group,with statistically significant difference(P<0.05).After treatment,gingival index(GI)and sulcus bleeding index(SBI)in the two groups decreased,and those in the GTR group were lower than those of the conventional group(both P<0.05).After treatment,interleukin-6(IL-6),matrix metallopro-teinase-8(MMP-8)and C-reactive protein(CRP)in the two groups decreased,and those were lower in the GTR group than in the conventional group(all P<0.05).After treatment,the scores of oral health-related quality of life in the two groups decreased,and that in the GTR group was lower than that of the conventional group(P<0.05).The incidence of adverse reactions in the GTR group was 4.44%(2/45),which was lower than that[20.00%(9/45)]of the conventional group(P<0.05).Conclusions GTR combined with orthodontic treatment can effectively improve the therapeutic effect of patients with malocclusion and periodontal disease,improve the periodontal health status,inhibit inflammation response,improve the quality of life,and reduce postoperative adverse reactions.
作者
王慧燕
邱荣华
沈芳
殷好
WANG Huiyan;QIU Ronghua;SHEN Fang;YIN Hao(Department of Stomatology,Anqing First People's Hospital,Anqing 246003,China)
出处
《山东医药》
CAS
2024年第16期33-37,共5页
Shandong Medical Journal
基金
安庆市科技计划项目(2018Z0012)。
关键词
错[牙合]畸形伴牙周病
牙周引导组织再生术
牙龈美容效果
牙周指标
炎症指标
安全性指标
malocclusion and periodontal disease
periodontal-guided tissue regeneration
gingival beauty effect
periodontal index
indicators of inflammation
safety index
