摘要
缺血性中风是我国居民致残的首要病因,治疗选择仍然有限。通腑法在缺血性中风治疗中已被证明具有显著疗效,但其作用机制尚不清楚。随着脑肠互动研究的进展,越来越多的证据表明脑肠互动在缺血性中风中起着重要作用。文章以“脑肠互动”为理论基础探讨了通腑法治疗缺血性中风的作用机理,从肠道菌群、脑肠肽、肠道代谢产物、肠道粘膜屏障等多个方面进行讨论阐述,总结出通腑法可以通过调节肠道菌群、脑肠肽含量、肠道代谢产物含量及修护肠道粘膜屏障等治疗缺血性中风,以期为阐明通腑法治疗缺血性中风的作用机制提供更多思路,具有重要的理论及临床价值。
Ischemic stroke is the leading cause of disability in China,and treatment options are still very limited.The method of dredging Fu-organs has been proved to have a significant effect in the treatment of ischemic stroke,but its mechanism is not clear.With the progress of brain-gut communication research,more and more evidence shows that brain-gut communication plays an important role during ischemic stroke.Based on the theory of"brain-gut interaction",this paper discusses the mechanism of Tongfu method in the treatment of ischemic stroke,and discusses the intestinal flora,brain-gut peptide,intestinal metabolites,intestinal mucosal barrier and other aspects.It is concluded that Tongfu method can treat ischemic stroke by regulating intestinal flora,brain-gut peptide content,intestinal metabolite content and repairing intestinal mucosal barrier.In order to provide more ideas for elucidating the mechanism of Tongfu method in the treatment of ischemic stroke,it has very important theoretical and clinical value.
作者
贺晨菲
马驰远
刘向哲
HE Chenfei;MA Chiyuan;LIU Xiangzhe(Encephalopathy Center of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;The First Clinical Medical College of Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2024年第3期617-621,共5页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
河南省卫生健康委员会河南省中医药科学研究专项课题(2023ZXZX1077):中风病痰热腑实证诊断标准的建立,负责人:刘向哲
河南省卫生健康委员会河南省中医药传承与创新人才工程(仲景工程)中医药学科领军人才项目(豫卫中医函【2021】8号),负责人:刘向哲
河南省科学技术厅重点研发与推广专项(科技攻关)(212102310360):基于关键证候的急性缺血性中风中医药干预方案循证评价研究,负责人:刘向哲。
关键词
缺血性中风
通腑法
脑肠互动
肠道菌群
脑肠肽
Ischemic stroke
Tongfu therapy
Brain-gut interaction
Gut microbiota
Brain-gut peptide
