摘要
烟酰胺腺嘌呤二核苷酸磷酸氧化酶(NADPH oxidase,NOX)是一类可以产生活性氧的跨膜蛋白,参与多种病理生理过程。NOX家族共有7个成员,其中NADPH氧化酶4(NADPH oxidase 4,NOX4)分布广泛且其活性取决于蛋白质表达水平,在多种恶性肿瘤中表达异常,参与肿瘤细胞增殖、转移、上皮间充质转化、治疗耐药等过程。本文总结了NOX4在多个系统肿瘤发生发展过程中的作用和治疗潜力,以期为进一步研究其相关功能机制及临床应用提供理论参考。
Nicotinamide adenine dinucleotide phosphate(NADPH)oxidase(NOX)is a kind of transmembrane proteins that can produce reactive oxygen species and participate in a variety of pathophysiological processes.There are seven members in the NOX family,among which NADPH oxidase 4(NOX4)is widely distributed and its activity depends on the expression of proteins.Its abnormal expression in many tumors is involved in tumor cell proliferation,metastasis,epithelial mesenchymal transformation,treatment of drug resistance and so on.This paper summarizes the role and therapeutic potential of NOX4 in the development of multiple systemic tumors,in order to provide theoretical reference for further study of its related functional mechanism and clinical application.
作者
闫文佳
卞伟
肖虹
YAN Wenjia;BIAN Wei;XIAO Hong(The First Clinical Medical College,Shanxi Medical University,Taiyuan 030000,China;Department of Basic Medicine,Shanxi Medical University,Taiyuan 030000,China;Department of Pathology,the First Hospital of Shanxi Medical University,Taiyuan 030000,China)
出处
《生命的化学》
CAS
2024年第5期910-917,共8页
Chemistry of Life
基金
山西省自然科学基金项目(202203021221186)。
关键词
NOX4
恶性肿瘤
活性氧
NADPH oxidase 4
malignant tumors
reactive oxygen species
