摘要
目的:多方面评估一种新型功效组合物五环精华对油敏性皮肤的舒缓功效。方法:以上海地区34名18~60岁的油敏性肤质健康女性受试者为研究对象,采用自体前后对照的方法来评估长期使用五环精华对油敏性皮肤的舒缓功效。结果:受试者连续使用五环精华4周后,皮肤的多项生理指标得到显著改善,包括角质层含水量增加13.29%,经表皮失水下降11.72%,温度下降1.91%,油脂分泌量减少21.21%,红斑指数下降7.70%,黑色素指数下降4.54%,色**度a值下降5.84%,色度L值增加5.68%,乳酸刺激2.5min后评分下降58.16%(均P<0.01)。结论:对于油敏性皮肤,五环精华能够有效增加皮肤含水量,减少油脂分泌和色素沉着,缓解炎症状态,提亮肤色且刺激性小,显著改善皮肤屏障功能,说明其具有皮肤舒缓和修复功效。
Objective:To comprehensively evaluate the soothing effects of a novel efficacy complex(referred to as“Penta-Ring essence”)on the skin of individuals with oily sensitivity.Methods:An in vivo experimental approach with 34 healthy female subjects aged 18-60 years with oily skin from the Shanghai area was employed.The soothing effect of a long-term use of Penta-Ring essence on oily and sensitive skin was evaluated by a method of autologous before-and-after control.Results:A number of physiological indicators of the skin were significantly improved after the Penta-Ring essence was continuously used for 4 weeks,including 13.29%increase in the water content of the stratum corneum,11.72%decrease transepidermal water loss,1.91%decrease in skin temperature,21.21%decrease in skin sebum,7.70%decrease in skin E value,4.54%decrease in M value,5.84%decrease in skin chroma a*value,5.68%increase in skin chroma L*value and 58.16%decrease in the score after 2.5 min lactate irritation(all P<0.01).Conclusion:For oily and sensitive skin,the Penta-Ring essence can effectively increase skin hydration,reduce oil secretion and pigmentation,relieve inflammation,brighten skin tone with minimal irritation and significantly improve skin barrier function,which demonstrate its efficacy in skin soothing and repair.
作者
陈宪策
季小凡
马彦云
刘庆梅
CHEN Xiance;JI Xiaofan;MA Yanyun;LIU Qingmei(Fudan University School of Life Sciences,Shanghai 200438,China;Department of Dermatology,Wusong Central Hospital,Shanghai 201900,China;Human Phenome Institute,Fudan University,Shanghai 200438,China;Department of Dermatology,Huashan Hospital,Fudan University,Shanghai 200040,China;Shanghai Skin Disease Research Institute,Shanghai 200040,China)
出处
《上海医药》
CAS
2024年第11期17-22,共6页
Shanghai Medical & Pharmaceutical Journal
基金
上海市科学技术委员会资助的基地项目(19DZ2250500)
复旦大学横向课题(SGH1323010)。
关键词
五环精华
油敏性皮肤
皮肤屏障
经表皮失水
舒缓功效
Penta-Ring essence
oil-sensitive skin
skin barrier
transepidermal water loss
soothing effects
