摘要
毛母质癌(PC)是一种罕见的恶性皮肤附属器肿瘤,好发于头颈部,发病人群通常为30岁以下或60~70岁中老年人群,呈双峰分布。其临床表现与某些皮肤肿瘤较为相似,容易发生误诊或漏诊。PC诊断主要依据组织病理学检查,其免疫组化染色,例如β-连环蛋白(β-catenin)、淋巴增强因子-1 (LEF-1)、尾源性转录因子2 (CDX2)、普列克底物蛋白同源样结构域家族A成员1蛋白(PhLDA1)、CD10、CD56等有助于鉴别诊断。PC局部侵袭性强,最常见区域淋巴结转移;扩大切除原发病灶仍是PC首选的治疗方法。本文重点围绕PC的临床特点、组织形态学特征、影像学表现、鉴别诊断、治疗及预后等最新研究进展进行综述。
Pilomatrical carcinoma(PC),a rare malignant cutaneous adnexal carcinoma,mainly occurs on the head and neck.The PC is more common among individuals aged below 30 years old or those between the ages of 60 and 70,showing a bimodal age distribution.Its clinical manifestations are similar to those of other skin tumors,making it prone to misdiagnosis or oversight.The definitive diagnosis of PC relies on histopathological examination of the skin biopsy specimen.Immunohistochemical staining can assist in distinguishing PC from other skin cancers based on valuable immunohistochemical markers,such asβ-catenin,LEF-1,CDX2,PhLDA1,CD10,CD56,etc.The PC exhibits robust localized aggressiveness,with regional lymph node metastasis being the most prevalent.The wide local excision of the primary lesions is the first-choice treatment for PC.This review summarizes the most updated knowledge on the clinical characteristics,histomorphologic features,imaging manifestations,differential diagnosis,treatment,and prognosis of PC.
作者
王鹏
韩军涛
WANG Peng;HAN Juntao(Department of Burns and Cutaneous Surgery,Xijing Hospital,Air Force Medical University,Xi'an 710032,China)
出处
《实用皮肤病学杂志》
2024年第3期163-166,共4页
Journal of Practical Dermatology
关键词
毛母质癌
组织病理学
分子遗传学
临床治疗
Pilomatrical carcinoma
Histopathology
Molecular genetics
Clinical treatment
