摘要
目的:探讨补阳还五汤联合醒脑开窍针刺对中风偏瘫患者认知功能、肢体功能的疗效及安全性。方法:78例中风偏瘫患者根据入院单双日的顺序分为观察组(n=41)和对照组(n=37)。对照组给予补阳还五汤,观察组在对照组治疗基础上给予醒脑开窍针刺。治疗后比较两组患者认知功能、肢体功能。结果:治疗后,观察组中枢神经特异性蛋白水平显著低于同期对照组(t=8.617,P=0.006),脑源性神经营养因子水平显著高于同期对照组(t=10.390,P<0.001);观察组大脑前动脉、后动脉和基底动脉的血流速度均显著高于同期对照组(P<0.05);观察组行走不稳、肢体麻木、乏力等中医证候积分均显著低于对照组(P<0.05);观察组NIHSS得分显著低于同期对照组(t=15.961,P<0.001),MMSE评分显著高于同期对照组(t=8.256,P=0.002);观察组FMA评分和Barthel指数均显著高于同期对照组(t=8.290,P=0.009;t=6.055,P=0.043)。结论:补阳还五汤联合醒脑开窍针刺可有效改善中风偏瘫患者的认知功能和肢体功能,提高患者生活质量。
Objective:To explore the therapeutic effect and safety of Buyang Huanwu Decoction combined with acupuncture of awaking brain to open orifice on cognitive function and limb function in patients with stroke hemiplegia.Methods:78 cases of patients with stroke hemiplegia were divided into observation group(n=41)and control group(n=37)according to the odd or even number day of admission to the hospital.The control group was given Buyang Huanwu Decoction,and the observation group was given acupuncture of awaking brain to open orifice on the basis of the treatment of the control group.The cognitive function and limb function were compared between the two groups after treatment.Results:after treatment,the central nervous specificity protein(S-100β)level of the observation group was significantly lower than that of the control group in the same period(t=8.617,P=0.006),while the level of brain-derived neurotrophic factor(BDNF)of the control group was significantly higher than that of the control group in the same period(t=10.390,P<0.001).The blood flow velocities of anterior cerebral artery(ACA),posterior cerebral artery(PCA)and basilar artery(BA)of the observation group were significantly higher than those of the control group(P<0.05).The TCM syndrome scores of walking instability,limb numbness and fatigue of the observation group were significantly lower than those of the control group(P<0.05).The National institutes of health stroke scale(NIHSS)scores of the observation group was significantly lower than that of the control group(t=15.961,P<0.001),while the mini-mental state examination(MMSE)score was significantly higher than that of the control group(t=8.256,P=0.002).The scores of Fugl-meyer assessment scale(FMA)and Barthel index(BI)of the observation group were significantly higher than those of the control group in the same period(t=8.290,P=0.009;t=6.055,P=0.043).Conclusion:Buyang Huanwu Decoction combined with acupuncture of awaking brain to open orifice can effectively improve the cognitive function and limb function as well as improving the life quality of patients with stroke hemiplegia.
作者
朱会斌
刘志华
陈豪
孙兆祺
郭鑫
ZHU Huibin;LIU Zhihua;CHEN Hao;SUN Zhaoqi;GUO Xin(The Second Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou Henan China 450002;The Second Affiliated Hospital to Henan University of Chinese Medicine/Henan Province Hospital of Traditional Chinese Medicine,Zhengzhou Henan China 450002)
出处
《中医学报》
CAS
2024年第8期1776-1780,共5页
Acta Chinese Medicine
基金
河南省中医药科学研究专项课题项目(2022ZY1065)
王松龄全国名老中医药专家工作室项目{国中医药人教发[2018]134号}。
关键词
中风偏瘫
补阳还五汤
醒脑开窍针刺
认知功能
肢体功能
stroke hemiplegia
Buyang Huanwu Decoction
acupuncture of awaking brain to open orifice
cognitive function
limb function
