摘要
视神经脊髓炎谱系疾病(NMOSDs)以抗水通道蛋白4(AQP4)抗体阳性NMOSDs最为多见,主要表现为反复发作的视神经炎和脊髓炎等,严重降低患者生活质量。近年来,对该病的诊断技术、诊断标志物和免疫治疗药物不断有新的认识,本文综述抗AQP4抗体阳性NMOSDs的诊断技术和诊断标志物新进展以及新的治疗药物,以促进对该病的诊断与治疗新技术的理解和应用,探索更多可能的临床诊断与治疗方法。
Neuromyelitis optica spectrum disorders(NMOSDs)are most common in anti-aquaporin 4(AQP4)antibody positive NMOSDs,which are characterized by recurrent episodes of optic neuritis and myelitis,etc.,and severely reduce the quality of life.In recent years,new insights into the diagnostic techniques,diagonstic markers,and immunotherapy of anti-AQP4 antibody positive NMOSDs have continued to emerge,and here we focus on synthesizing new advances in the diagnostic techniques and diagonstic markers of anti-AQP4 antibody positive NMOSDs and the most recent recommendations for its treatment,in hopes of summarizing to promote the understanding and application of new diagnostic and therapeutic techniques for anti-AQP4 antibody positive NMOSDs in China,and to explore more possible clinical diagnostic and therapeutic approaches.
作者
许鸿嘉
舒崖清
王蘋
李蕃
许顺良
邱伟
马晓宇
Hong-jia XU;Ya-qing SHU;Pin WANG;Fan LI;Shun-liang XU;Wei QIU;Xiao-yu MA(Department of Neurology,The Second Hospital of Shandong University,Ji'nan 250033,Shandong,China;Department of Neurology,The Third Affiliated Hospital,Sun Yat-Sen University,Guangzhou 510630,Guangdong,China)
出处
《中国现代神经疾病杂志》
CAS
北大核心
2024年第5期308-314,共7页
Chinese Journal of Contemporary Neurology and Neurosurgery
基金
山东大学第二医院培育基金资助项目(项目编号:2023YP01)
国家自然科学基金资助项目(项目编号:82071343)
国家自然科学基金资助项目(项目编号:82371354)
国家自然科学基金资助项目(项目编号:81701188)
广东省基础与应用基础研究基金资助项目(项目编号:2021A1515010393)
广东省广州市科技计划重点研发计划项目(项目编号:2023B03J1347)
广东省广州市校(院)联合资助项目(项目编号:202201020415)。
