摘要
目的对射血分数降低心力衰竭急性发作期患者使用达格列净片联合麝香保心丸进行治疗的效果做出分析。方法选择160例心力衰竭患者,该类患者均处在急性发作期,且射血分数降低,在随机抽样法方式下将患者划分成常规组和研究组,各80例。常规组患者使用达格列净片治疗,研究组使用达格列净片联合麝香保心丸治疗。对比分析两组患者的治疗效果、心室功能水平、心力衰竭标志物、中医证候积分。结果研究组治疗总有效率为98.75%,高于常规组的90.00%(χ^(2)=5.768,P<0.05)。研究组左室收缩末期内径、左室射血分数、左室舒张末内径分别为(35.13±2.08)mm、(58.71±2.87)%、(52.85±2.56)mm,均优于常规组的(39.56±2.51)mm、(43.10±2.43)%、(56.81±3.13)mm(t=12.154、37.127、8.759,P<0.05)。研究组N末端脑钠肽前体、血浆内脑钠肽水平分别为(1510.36±160.35)、(601.40±98.87)ng/L,均优于常规组的(2219.63±152.58)、(829.53±121.36)ng/L(t=28.660、13.035,P<0.05)。研究组治疗1、2周的中医证候积分分别为(16.08±6.84)、(11.27±9.71)分,均低于常规组的(24.28±10.39)、(20.25±13.26)分(t=5.896、4.887,P<0.05)。结论为射血分数降低心力衰竭急性发作期患者使用达格列净片联合麝香保心丸进行治疗,能够改善患者心室功能,降低患者心力衰竭标志物水平,提升治疗效果,临床应用价值较高。
Objective To analyze the effect of dapagliflozin tablets combined with Shexiang Baoxin pills in the treatment of acute episode of heart failure with reduced ejection fraction.Methods A total of 160 patients with acute episode of heart failure with reduced ejection fraction were selected as the study subjects.The patients were randomly divided into a conventional group and a study group,each consisting of 80 patients.The conventional group was treated with dapagliflozin tablets,while the study group was treated with dapagliflozin tablets combined with Shexiang Baoxin pills.The therapeutic effect,ventricular function level,biomarkers of heart failure and traditional Chinese medicine syndrome score of the two groups were compared and analyzed.Results The total effective rate of the study group was 98.75%,which was higher than 90.00% of the conventional group(χ^(2)=5.768,P<0.05).The left ventricular end-systolic diameter,left ventricular ejection fraction and left ventricular end-diastolic diameter of the study group were(35.13±2.08)mm,(58.71±2.87)% and(52.85±2.56)mm,which were superior to(39.56±2.51)mm,(43.10±2.43)% and(56.81±3.13)mm of the conventional group(t=12.154,37.127,8.759;P<0.05).The levels of N-terminal pro-brain natriuretic peptide and plasma brain natriuretic peptide in the study group were(1510.36±160.35)and(601.40±98.87)ng/L,which were better than(2219.63±152.58)and(829.53±121.36)ng/L in the conventional group(t=28.660,13.035;P<0.05).The traditional Chinese medicine syndrome score of the study group were(16.08±6.84)and(11.27±9.71)points after 1 and 2 weeks of treatment,which were lower than(24.28±10.39)and(20.25±13.26)points of the conventional group(t=5.896,4.887;P<0.05).Conclusion The use of dapagliflozin tablets combined with Shexiang Baoxin pills for the treatment of acute episode of heart failure with reduced ejection fraction can improve ventricular function,reduce biomarkers of heart failure,improve therapeutic effect,and have high clinical application value.
作者
王小波
WANG Xiao-bo(Pharmacy Department,Chengwu County People's Hospital,Heze 274200,China)
出处
《中国现代药物应用》
2024年第13期19-22,共4页
Chinese Journal of Modern Drug Application
关键词
达格列净片
麝香保心丸
射血分数
心力衰竭
急性发作期
疗效
Dapagliflozin tablets
Shexiang Baoxin pills
Ejection fraction
Heart failure
Acute episode
Efficacy
