摘要
目的 分析玫瑰痤疮患者病原微生物分布特点及不同类型玫瑰痤疮患者与幽门螺杆菌感染的相关性。方法 选取2021-2023年本院皮肤科接诊的253例玫瑰痤疮患者及253例皮肤健康志愿者为研究对象。搜集整理患者临床资料,采集所有参与本次研究者面部标本,进行毛囊蠕形螨、马拉色菌检测,对比分析不同性别、年龄患者毛囊蠕形螨与马拉色菌的检出情况。对临床分型为红斑毛细血管扩张型与丘疹脓疱型患者进行幽门螺杆菌检测,对比不同类型玫瑰痤疮患者幽门螺杆菌的感染情况。结果 253例玫瑰痤疮患者中,142例为红斑毛细血管扩张型,96例为丘疹脓疱型,15例为肥大增生型。54.94%为单一部位发生皮损(139/253),主要为两颊,45.06%为两个部位发生皮损(114/253),主要为两颊与鼻部。33.60%患者病程<1年(85/253),30.04%患者病程为1~3年(76/253),20.95%患者病程为3~5年(53/253),15.42%患者病程>5年(39/253)。58.89%患者自觉干燥、紧绷(149/253),57.31%患者自觉灼热(145/253),37.15%患者自觉刺痛(94/253),34.39%患者自觉瘙痒(87/253),9.88%患者自觉肿胀(25/253),7.11%患者自觉眼部不适(18/253)。玫瑰痤疮患者毛囊蠕形螨阳性率63.24%(160/253),马拉色菌阳性率70.36%(178/253)。健康对照者毛囊蠕形螨阳性率15.81%(40/253),马拉色菌阳性率13.83%(35/253)。玫瑰痤疮患者与健康者的毛囊蠕形螨阳性率、马拉色菌阳性率差异有统计学意义(P<0.05)。玫瑰痤疮患者中共检出马拉色菌178株,包括62株球形马拉色菌,56株糠秕马拉色菌,27株合轴马拉色菌,21株厚皮马拉色菌,7株限制马拉色菌,5株斯洛菲马拉色菌。男性玫瑰痤疮患者毛囊蠕形螨阳性率60.34%(35/58),女性阳性率64.10%(125/195),差异无统计学意义(P>0.05)。男性玫瑰痤疮患者马拉色菌阳性率89.66%(52/58),女性阳性率64.62%(126/195),差异有统计学意义(P<0.05)。≤25岁玫瑰痤疮患者毛囊蠕形虫阳性率56.67%(34/60),25~40岁阳性率75.64%(59/78),≥40岁阳性率58.26%(67/115),差异无统计学意义(P>0.05)。6≤25岁玫瑰痤疮患者出马拉色菌阳性率71.67%(43/60),25~40岁阳性率60.26%(47/78),≥40岁阳性率76.52%(88/115),不同年龄组患者差异无统计学意义(P>0.05)。红斑毛细血管扩张型患者68例幽门螺杆菌阳性率47.89%(68/142),丘疹脓疱型患者阳性率76.04%(73/96),感染率差异有统计学意义(P<0.05)。结论 玫瑰痤疮患者临床分型以红斑毛细血管扩张型与丘疹脓疱型为主,皮损部位主要为两颊。玫瑰痤疮患者毛囊蠕形螨阳性率、马拉色菌阳性率高于健康者,不同性别患者的马拉色菌阳性率差异有统计学意义。丘疹脓疱型患者幽门螺杆菌阳性率高于红斑毛细血管扩张型患者,不同类型玫瑰痤疮患者的幽门螺杆菌感染情况具有差异性。
Objective To analyze the distribution characteristics of pathogenic microorganisms in patients with rosacea and the correlation between different types of rosacea patients and Helicobacter pylori infection. Methods 253 patients with rosacea and 253 healthy skin volunteers treated by our dermatology department from 2021 to 2023 were selected as the study subjects. The clinical data of patients was collected and organized. The facial specimens of all participants were collected in this study, and the detection of D. folliculiformis and Malassezia were conducted. The detection of D. folliculiformis and Malassezia in patients of different genders and ages were compared and analyzed. The detection of H. pylori were conducted in patients with erythematous telangiectasia and papular pustular type. The infection status of H. pylori in patients with different types of rosacea were compared. Results Among 253 patients with rosacea, 142 were erythematous telangiectasia type, 96 were papular pustular type, and 15 were hypertrophic type.54.94% had skin lesions in a single area(139/253),mainly on the cheeks, and 45.06% had skin lesions in two areas(114/253),mainly on the cheeks and nose. 33.60% of patients had a disease course time of less than 1 year(85/253),30.04% had a disease course time of 1-3 years(76/253),20.95% had a disease course time of 3-5 years(53/253),and 15.42% had a disease course time of more than 5 years(39/253).58.89% of patients felt dry and tight(149/253),57.31% felt burning(145/253),37.15% felt stinging(94/253),34.39% felt itching(87/253),9.88% felt swelling(25/253),and 7.11% felt eye discomfort(18/253). The positive rate of D. folliculiformis and Malassezia in patients with rosacea was 63.24%(160/253) and 70.36%(178/253),respectively.The positive rate of D. folliculiformis and Malassezia in healthy controls was 15.81%(40/253) and 13.83%(35/253),respectively. There was a statistically significant difference in the positive rates of D. folliculiformis and Malassezia between patients with rosacea and healthy individuals(P<0.05). A total of 178 strains of Malassezia were detected in patients with rosacea, including 62 strains of Malassezia globosa,56 strains of Malassezia furfur,27 strains of syncytial Malassezia,21 strains of Malassezia pachydermatis,7 strains of restricted Malassezia,and 5 strains of Slovenia Malassezia.The positive rate of D. folliculi in male patients with rosacea was 60.34%(35/58),while in female, it was 64.10%(125/195),and there was no statistically significant difference(P>0.05). The positive rate of Malassezia in male patients with rosacea was 89.66%(52/58),while in female, it was 64.62%(126/195),andthere was a statistically significant difference(P<0.05).The positivity rate of hair follicle demodex in patients with rosacea ≤ 25 years old was 56.67%(34/60),the positivity rate between 25 and 40 years old was 75.64%(59/78),and the positivity rate of patents ≥ 40 years old was 58.26%(67/115). There was no statistically significant difference in the positivity rate among patients of different age groups(P>0.05). The positive rate of Malassezia in patients with rosacea aged ≤ 25 was 71.67%(43/60),the positive rate of aged 25-40 was 60.26%(47/78),and the positive rate of aged ≥ 40 was 76.52%(88/115). There was no statistically significant difference among patients of different age groups(P>0.05). The positive rate of H. pylori in 68 patients with erythematous telangiectasia was 47.89%(68/142),while in patients with papular and pustular lesions, the positive rate was 76.04%(73/96),and the difference was statistically significant(P<0.05). Conclusion The clinical classification of patients with rosacea was mainly erythematous telangiectasia dilation type and papular pustular type, with skin lesions mainly on the cheeks.The positive rates of D. folliculiformis and Malassezia in patients with rosacea were higher than those in healthy individuals, and there was a statistically significant difference in Malassezia positive rates among patients of different genders. The positivity rate of H. pylori in patients with papular pustular type was higher than that in patients with erythematous capillary dilation type, and there were differences in H. pylori infection among patients with different types of rosacea.
作者
王红兰
庄永灿
王洪梅
WANG Honglan;ZHUANG Yongcan;WANG Hongmei(Department of Dermatology,Quanzhou First Hospital,Quanzhou 362000,Fujian,China;Department of Dermatology,Shixiong Hospital,Hui'an County)
出处
《中国病原生物学杂志》
CSCD
北大核心
2024年第8期963-966,971,共5页
Journal of Pathogen Biology
