摘要
目的为临床早诊断、早治疗脑型肺吸虫病提供参考。方法回顾性分析2011年1月至2022年12月十堰市人民医院(湖北医药学院附属人民医院)3例分别以“3 d内抽搐2次”“头晕、肢体麻木2 d”“头痛、恶心、发热3 d”为主诉脑型肺吸虫病患儿临床资料。结果3例患儿均有生食疫区溪蟹史。肺吸虫抗原皮内试验(PAIT)均为阳性。患儿嗜酸性粒细胞(EOS)均显著增高。1例患儿头颅MRI检查显示“颅内血肿形成并有隧道征”,2例患儿头颅MRI检查无异常。肺吸虫病积分诊断量表均达到诊断肺吸虫病标准。吡喹酮驱虫(25 mg/kg、3次/d,服用2 d,间隔7 d进入下一疗程;2~5个疗程)治疗,3例患儿经治疗神经系统症状完全控制、EOS恢复正常,达到临床治愈。结论脑型肺吸虫病脑患儿MRI可无异常,EOS和肺吸虫病积分诊断量表在脑型肺吸虫病诊治中有重要价值。
Objective To provide reference for early diagnosis and early treatment of cerebral paragonimiasis.Methods The clinical data of 3 children with cerebral paragonimiasis from January 2011 to December 2022 were analyzed,retrospectively,with“two convulsions within 3 days”,“dizziness,limb numbness for 2 days”and“headache,nausea and fever for 3 days”as the main complaints in Renmin Hospital,Hubei University of Medicine.Results All children had a history of eating crabs in epidemic areas.Paragonimus antigen skin test(PAIT)were all positive.Eosinophils(EOS)of 3 children increased significantly.One child’s head MRI showed“intracranial hematoma with tunnel sign”.There were no abnormality in MRI examination of the othoer 2 children’s heads.The clinical data of 3 children reached the standard of paragonimiasis diagnosis with the scale of paragonimiasis integral diagnosis.Praziquantel(25 mg/kg,taken three times a day for 2 days,with an interval of 7 days,entered the next course of treatment;totally 2-5 courses).After treatment,3 children’s eurological symptoms were completely controlled,EOS returned to normal,and all achieved clinical cure.Conclusions Cerebral MRI examination of paragonimiasis can be normal,while EOS and paragonimiasis integral diagnostic scale are of impotpant value in the diagnosis and treatment of cerebral paragonimiasis.
作者
郭利琴
毛静
刘鑫华
刘康霄
杨军杰
钟炎平
赵琴
饶荣
李凤霞
雷旭
谭华炳
Guo Liqin;Mao Jing;Liu Xinhua;Liu Kangxiao;Yang Junjie;Zhong Yanping;Zhao Qin;Rao Rong;Li Fengxia;Lei Xu;Tan Huabing(Department of Infectious Diseases,Hepatology Institute,Renmin Hospital,Hubei University of Medicine,Shiyan 442000,China;Department of Pediatrics,Fangxian Renmin Hospital,Fangxian 442100,China;Department of Cardiology,Heyuan People’s Hospital,Heyuan,517001,China;Shiyan Key Laboratory of Virology,Hubei University of Medicine,Shiyan 442000,China;Medical Department,Zijing Hospital Affiliated to Wuhan University of Science and Technology,Wuhan 430062,China)
出处
《中华实验和临床感染病杂志（电子版）》
CAS
2024年第2期113-116,共4页
Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)
基金
国家自然科学基金青年科学基金资助项目(No.82002149)
2014年度湖北省教育厅科学研究计划(No.Q20142106)
2019年十堰市科学技术研究与开发项目计划(No.19K67)
2021年十堰市科学技术研究与开发项目计划(No.2021K65)。
关键词
肺吸虫病
脑型
核磁共振
嗜酸性粒细胞
肺吸虫病积分诊断量表
Paragonimiasis
Cerebral
Magnetic resonance imaging
Eosinophils
Integrated diagnostic scale for paragonimiasis
