摘要
作为一种新型铁依赖性细胞死亡方式,铁死亡特定过程就是含有多不饱和脂肪酸(polyunsaturated fatty acid,PUFA)的磷脂在胞膜上过度积累发生过氧化。脂滴时刻处于生成和分解的动态转换,在调节脂质代谢中起着核心作用,并时刻处于生成和分解的动态转换。脂滴代谢与铁死亡的发生密切相关,在铁死亡异常导致疾病中发挥重要作用。本综述首先着重介绍脂滴代谢过程及其对PUFA存储和释放的影响,并进一步阐明脂滴代谢对铁死亡调控机制及关键调节蛋白,以期揭示脂滴与铁死亡间的内在联系,为铁死亡相关疾病的临床治疗提供新思路。
As a novel iron-dependent form of cell death,ferroptosis is characterized by the excessive accumulation of phospholipids containing polyunsaturated fatty acids(PUFA)on the cell membrane and peroxidation.Lipid droplets are always in the dynamic transition of generation and decomposition,play a central role in regulating lipid metabolism,and are always in the dynamic transition of generation and decomposition.Lipid droplet metabolism is closely related to the occurrence of ferroptosis and plays an important role in the disease caused by ferroptosis.This review firstly focuses on the lipid droplet metabolism process and its effects on the storage and release of PUFA,and further elucidates the regulatory mechanism and key regulatory proteins of lipid drop metabolism on ferroptosis,in order to reveal the intrinsic relationship between lipid droplets and ferroptosis,and provide a new strategy for disease prevention and treatment.
作者
姜全奥
邓然
夏仕林
江小慢
许静
吴虹
JIANG Quan-ao;DENG Ran;XIA Shi-lin;JIANG Xiao-man;XU Jing;WU Hong(School of Integrated Traditional and Western Medicine,Anhui University of Chinese Medicine,Hefei 230012,China;Anhui Province Key Laboratory of Research and Development of Chinese Medicine,Key Lab of Xin′an Medicine,Ministry of Education,School of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,China)
出处
《药学学报》
CAS
CSCD
北大核心
2024年第7期1897-1904,共8页
Acta Pharmaceutica Sinica
基金
国家自然科学基金面上资助项目(81874360)
安徽省自然科学基金青年项目(2308085QH300)
安徽省高等学校科学研究项目重大项目(2022AH050453)。
关键词
脂滴
铁死亡
多不饱和脂肪酸
单不饱和脂肪酸
脂解
脂滴合成
lipid droplet
ferroptosis
polyunsaturated fatty acid
monounsaturated fatty acid
lipolysis
lipid droplet biogenesis
