摘要
目的探讨慢性萎缩性胃炎并发胃真菌病的危险因素,提供防治依据。方法回顾性分析2021年7月至2023年7月医院收集的慢性萎缩性胃炎患者255例,统计胃真菌病发生情况,将是否并发胃真菌病分为并发组和未并发组,对年龄、性别、肥胖、病程、糖尿病、高血压、长期服用阿司匹林(≥半年)、血清白蛋白、C-反应蛋白、胃黏膜异常增生、胃黏膜萎缩程度等因素进行单因素及多因素logistics回归分析,寻找慢性萎缩性胃炎并发胃真菌病的危险因素并给出对策。结果慢性萎缩性胃炎未并发胃真菌病234例(91.76%);并发胃真菌病21例(8.24%),其中白念珠菌感染19例(90.48%),治疗后19例治愈且真菌镜检阴性;曲霉感染2例(9.52%),治疗后2例治愈且真菌镜检阴性。经单因素分析,未并发组与并发组年龄≥65岁、饮酒史、糖尿病、服用阿司匹林、病程≥20年、C反应蛋白水平、胃黏膜萎缩程度、血清白蛋白水平存在差异(P<0.05),而性别、肥胖、幽门螺旋杆菌感染、吸烟、高血压、胃黏膜异常增生无差异(P>0.05)。经过多因素分析,年龄≥65岁、饮酒史、糖尿病、服用阿司匹林、病程≥20年、胃黏膜萎缩程度是慢性萎缩性胃炎并发胃真菌病的危险因素,血清白蛋白水平是保护因素(P<0.05)。结论慢性萎缩性胃炎并发胃真菌病存在诸多危险因素,宜采取针对性防治对策。
Objective To explore the risk factors of chronic atrophic gastritis complicated with gastric mycosis and provide a basis for prevention.Methods Totally 255 patients with chronic atrophic gastritis collected in the hospital from July 2021 to July 2023 were retrospectively analyzed.The incidence of gastric mycosis was statistically analyzed.Whether gastric mycosis was complicated or not,the cases were divided into two groups:the concurrent group and the non concurrent group.Age,gender,obesity,course of disease,diabetes,hypertension,long-term aspirin use(≥half a year),serum albumin,CRP,gastric mucosal dysplasia Single factor and multivariate logistic regression analysis were conducted on factors such as the degree of gastric mucosal atrophy to identify risk factors for chronic atrophic gastritis complicated with gastric fungal disease and provide strategies.Result There were 21 cases(8.24%)of concurrent gastric fungal diseases,among which 19 caseswere infected with Candida albicans.After treatment,19 cases were cured and fungal microscopy tests were negative.Two cases were infected with Aspergillus,and after treatment,two cases were cured and fungal negative under microscopy.By single factor analysis,there were differences between the non complicated group and the complicated group in age≥65 years,drinking history,diabetes,aspirin,course of disease≥20 years,CRP level,gastric mucosal atrophy,serum albumin level(P<0.05),and there were no differences in gender,obesity,Helicobacter pylori infection,smoking,hypertension,and gastric mucosal dysplasia(P>0.05).Through multivariate analysis,age≥65 years,drinking history,diabetes,taking aspirin,course of disease≥20 years,degree of gastric mucosa atrophy were risk factors of chronic atrophic gastritis complicated with gastric mycosis,and serum albumin level was protective factor(P<0.05).Conclusion There are many risk factors for chronic atrophic gastritis complicated with gastric mycosis,and targeted prevention and treatment measures should be taken.
作者
肖洪斌
李继志
XIAO Hongbin;LI Jizhi(Orthopedic Hospital of Dazhou City,Sichuan Province,Dazhou 635000,China;Chongqing Red Cross Hospital(Jiangbei District People's Hospital),Chongqing 400020,China)
出处
《中国真菌学杂志》
CSCD
2024年第3期224-228,234,共6页
Chinese Journal of Mycology
关键词
慢性萎缩性胃炎
胃真菌病
危险因素
chronic atrophic gastritis
gastric mycosis
risk factors
