摘要
目的:探讨与分析脊柱微创通道镜辅助下融合术对腰椎退行性疾病患者血清P物质(SP)、β-内啡肽(β-EP)的影响。方法:选取2020年1月-2022年12月我院收治的130例腰椎退行性疾病患者为研究对象,采用随机数字表法将其分为研究组与对照组,各65例。对照组采用后外侧植骨融合手术治疗,研究组采用脊柱微创通道镜辅助下融合术治疗,记录2组围手术期指标、术后1个月并发症的发生情况、治疗效果SP、β-EP变化情况。结果:和对照组比较,研究组的术中失血量、术后引流量均更少,在手术及术后住院方面花费的时间均更短,组间差异有统计学意义(P<0.05)。2组术后1个月的SP、β-EP均少于术前1 d,组间差异有统计学意义(P<0.05),研究组术后1个月的SP、β-EP均少于对照组,组间差异有统计学意义(P<0.05)。研究组术后1个月内的脑脊液渗漏、切口感染、神经根痛、腰椎间隙感染等不良反应发生率为1.54%,低于对照组的10.77%,差异有统计学意义(P<0.05)。术后1个月,研究组的治疗总有效率为96.92%,高于对照组的84.62%,差异有统计学意义(P<0.05)。结论:脊柱微创通道镜辅助下融合术在腰椎退行性疾病的应用能促进患者康复,减少对患者的创伤,减少SP、β-EP,还能降低患者的并发症发生率,提高患者的总体疗效。
Objective:To investigate and analyze the effect of minimally invasive spinal fusion on serum substance P(SP)andβ-endorphin(β-EP)in patients with lumbar degenerative diseases.Methods:130 patients with lumbar degenerative diseases admitted to our hospital from January 2020 to December 2022 were selected as the research objects.According to the random number table method,they were divided into a study group and a control group,65 cases in each group.The control group was treated with posterolateral bone grafting and fusion surgery,and the study group was treated with minimally invasive spinal fusion surgery.The perioperative indicators,complications at 1 month after surgery,therapeutic effects,and changes in serum SP andβ-EP levels were recorded.Results:Compared with the control group,the intraoperative blood loss and postoperative drainage volume in the study group were less,and the time spent in operation and postoperative hospital stay was shorter,the difference between the two groups was statistically significant(P<0.05).The levels of serum SP andβ-EP 1 month after operation in the two groups were lower than those 1 day before operation,and the differences between the two groups were statistically significant(P<0.05).The levels of serum SP andβ-EP 1 month after operation in the study group were lower than those in the control group,and the differences between the two groups were statistically significant(P<0.05).The incidence of adverse reactions such as cerebrospinal fluid leakage,incision infection,nerve root pain and lumbar intervertebral space infection within 1 month after operation in the study group was 1.54%,which was lower than 10.77%in the control group,and the difference was statistically significant(P<0.05).One month after the operation,the total effective rate of the study group was 96.92%,which was higher than 84.62%of the control group,and the difference was statistically significant(P<0.05).Conclusion:The application of minimally invasive spinal arthroscopy assisted fusion in lumbar degenerative diseases can promote the rehabilitation of patients,reduce the trauma to patients,reduce the release of serum SP andβ-EP,reduce the incidence of complications,and improve the overall curative effect of patients.
作者
郭姣娜
GUO Jiao na(Department of clinical laboratory,Inner Mongolia mental health center,Hohhot,Inner Mongolia 010010)
出处
《中国伤残医学》
2024年第7期52-55,共4页
Chinese Journal of Trauma and Disability Medicine
关键词
腰椎退行性疾病
脊柱微创通道镜
融合术
并发症
Β-内啡肽
P物质
Lumbar degenerative disease
Minimally invasive spinal channel lens
Fusion
Complications
β-endorphin
Substance P
