摘要
目的研究养心健脾汤对心力衰竭(heart failure,HF)患者的疗效及心率变异性、血清因子的影响。方法选取2022年1月至2023年10月我院收治的100例HF患者为研究对象,根据治疗方案分为对照组和研究组,各50例。对照组采用曲美他嗪治疗,研究组在对照组基础上加用养心健脾汤治疗。比较两组临床疗效、治疗前后中医证候积分、心率变异性指标[正常窦性心搏间期标准差(SDNN)、正常相邻窦性心搏间期差值的均方根(RMSSD)、全程每5 min NN节段的窦性RR间期标准差(SDANN)、相邻窦性心搏间期差值>50 ms心搏数百分比(PNN50)]、血清细胞因子[超敏C反应蛋白(hs-CRP)、B型脑利钠肽(BNP)、组蛋白脱乙酰酶2(HDAC2)、分泌型卷曲相关蛋白2(SFRP2)]水平、不良反应发生率。结果研究组临床总有效率(96.00%)高于对照组(82.00%)(P<0.05);治疗1个月后,研究组水肿、气喘、心悸、畏寒肢冷评分低于对照组(P<0.05);治疗1个月后,研究组SDNN、RMSSD、SDANN、PNN50高于对照组(P<0.05);治疗1个月后,研究组血清hs-CRP、BNP、HDAC2水平低于对照组,SFRP2水平高于对照组(P<0.05);研究组不良反应总发生率(12.00%)与对照组(8.00%)相比,差异无统计学意义(P>0.05)。结论采用养心健脾汤与曲美他嗪联合治疗可有效促进HF患者心率变异性改善,缓解炎症状态及临床症状,增强疗效,安全性良好。
Objective To study the efficacy and effects of Yangxin JianPi decoction on heart rate variability and serum factors in patients with heart failure(HF).Methods A total of 100 HF patients admitted to our hospital from January 2022 to October 2023 were retrospectively selected and divided into control group and study group according to the treatment plan,with 50 cases in each group.The control group was treated with trimetazidine,and the study group was treated with Yangxin JianPi Decoction on the basis of the control group.The clinical efficacy,TCM pattern scores,heart rate variability indexes[standard deviation of normal sinus heart interval(SDNN),root mean square of normal adjacent sinus heart interval difference(RMSSD),standard deviation of sinus RR interval per 5 minNN segment(SDANN),difference between adjacent sinus heart beats>%of 50 ms heart beat rate(PNN50)]serum cytokines[hypersensitive C-reactive protein(hs-CRP),brain natriuretic peptide B type B(BNP),Histone deacetylase 2(HDAC2),secreted coil-associated protein 2(SFRP2)]levels,and incidence of adverse reactions were compared between the two groups.Results The total clinical effective rate of the study group(96.00%)was higher than that of the control group(82.00%)(P<0.05),the scores of edema,asthma,palpitations and chills in the study group were lower than those in the control group(P<0.05)after 1 month of treatment,the levels of SDNN,RMSSD,SDANN and PNN50 in the study group were higher than those in the control group(P<0.05)after 1 month of treatment,and the serum levels of hs-CRP,BNP and HDAC2 in the study group were lower than those in the control group after 1 month of treatment.The level of SFRP2 was higher than that of the control group(P<0.05),and the total incidence of adverse reactions in the study group(12.00%)was not significantly different from that in the control group(8.00%)(P>0.05).Conclusion The combination of Yangxin JianPi decoction and trimetazidine can effectively promote the improvement of heart rate variability,alleviate the inflammatory state and clinical symptoms,enhance the efficacy,and have good safety in HF patients.
作者
冯莉
邓华夫
周先炎
FENG Li(Nanyang Second People’s Hospital,Nanyang 473000,Henan,China)
出处
《牡丹江医学院学报》
2024年第4期40-43,共4页
Journal of Mudanjiang Medical University
基金
南阳市科技攻关计划项目(KJGG078)。
关键词
心力衰竭
养心健脾汤
曲美他嗪
疗效
心率变异性
Heart failure
Yangxin JianPi decoction
Trimetazidine
Curative effect
Heart rate variability
