摘要
目的:探讨分析微针射频(Microneedle radiofrequency,MRF)联合重组牛碱性成纤维细胞生长因子(Recombinant bovine basic fibroblast growth factor,rb-bFGF)凝胶治疗早期面部痤疮瘢痕患者的疗效。方法:选取2022年1月-2023年6月马鞍山市妇幼保健院收治的面部痤疮瘢痕患者62例,据简单随机法分为单一组(n=31,MRF治疗)和联合组(n=31,MRF联合rb-bFGF凝胶治疗),2个月1次,共治疗6个月。比较两组临床疗效、水肿时间、红斑消退时间及结痂时间;于治疗前后对比瘢痕基底深度、痤疮瘢痕权重(Echelle d'evaluation clinique des cicatrices d'acne,ECCA)评分、温哥华瘢痕量表(Vancouver scar scale,VSS);并记录不良反应。结果:联合组总有效率较单一组更高(P<0.05)。联合组水肿时间、红斑消退时间及结痂时间均短于单一组(P<0.05)。与治疗前比较,治疗2个月、6个月后两组瘢痕基底深度、ECCA及VSS评分均降低,且联合组上述指标较单一组更低(P<0.05)。联合组不良反应低于单一组(P<0.05)。结论:微针射频联合rb-bFGF凝胶治疗面部痤疮瘢痕患者疗效显著,不仅可改善瘢痕症状,还可促使瘢痕快速恢复,减少不良反应。
Objective To explore the curative effect of microneedle radiofrequency(MRF)combined with recombinant bovine basic fibroblast growth factor(rb-bFGF)gel in patients with early facial acne scars.Methods A total of 62 patients with facial acne scars at Ma'anshan Maternal and Child Health Hospital were enrolled between January 2022 and June 2023.According to the simple randomization method,they were divided into the single group(n=31,MRF)and the combination group(n=31,MRF combined with rb-bFGF gel).All patients were treated for 6 months(once every 2 months).The clinical curative effect,edema time,recession time of erythema and escharosis time,depth of scar base,scores of Echelle d'evaluation clinique des cicatrices d'acne(ECCA),and Vancouver Scar Scale(VSS)were compared between the two groups before and after treatment.The adverse reactions were recorded.Results The total response rate of the combination group was higher than that of the single group(P<0.05).The edema time,recession time of erythema,and escharosis time in the combination group were shorter than those in the single group(P<0.05).After 2 and 6 months of treatment,the depth of the scar base,ECCA,and VSS scores were decreased in both groups,which were lower in the combination group than in the single group(P<0.05).The incidence of adverse reactions in the combination group was lower than that in the single group(P<0.05).Conclusion The curative effect of MRF combined with rb-bFGF gel is significant in patients with facial acne scars,which can not only improve scar symptoms but also promote rapid scar recovery and reduce adverse reactions.
作者
李倩云
徐建荣
张凡
LI Qianyun;XU Jianrong;ZHANG Fan(Department of Dermatology and Venereology,Ma'anshan Maternal and Child Health Hospital,Ma'anshan 243000,Anhui,China)
出处
《中国美容医学》
CAS
2024年第8期112-115,共4页
Chinese Journal of Aesthetic Medicine
关键词
微针射频
重组牛碱性成纤维细胞生长因子凝胶
面部痤疮瘢痕
疗效
microneedle radiofrequency
recombinant bovine basic fibroblast growth factor gel
facial acne scar
curative effect
