摘要
目的探讨早期口腔鳞状细胞癌(OSCC)浸润深度(DOI)和侵袭模式(POI)在其复发预测和预后评价中的价值。方法回顾性收集109例原发OSCC患者资料。临床资料分类变量的比较采用卡方检验。临床资料与肿瘤复发的相关性研究采用单因素和多因素Logistic回归分析。临床资料与患者总体生存期的相关性研究采用Cox回归分析。结果单因素分析结果表明,POI、DOI和病理分级与早期OSCC复发及不良预后具有相关性。多因素Logistic回归分析显示,DOI为OSCC复发(OR=4.515,95%CI:1.283~15.894,P<0.05)及预后(HR=2.993,95%CI:1.225~7.317,P<0.05)的影响因素。OSCC的POI与DOI间有高度相关性。结论DOI≥5 mm被认为是早期OSCC复发和不良预后的相关因素。
Objective To investigate the value of depth of invasion(DOI)and pattern of invasion(POI)in predicting recurrence and evaluating prognosis of early oral squamous cell carcinoma(OSCC).Methods Data of 109 patients with primary OSCC were retrospectively collected.The chi-square test was used to compare categorical variables of clinical data.Univariate and multivariate Logistic regression analyses were used to analyze the correlation between clinical data and tumor recurrence.Cox regression analysis was used to analyze the correlation between clinical data and overall survival of patients.Results Univariate analysis showed that POI,DOI and pathological grade were correlated with recurrence and poor prognosis of early OSCC.Multivariate Logistic regression analysis indicated that DOI was an influencing factor for OSCC recurrence(OR=4.515,95%CI,1.283 to 15.894,P<0.05)and prognosis(HR=2.993,95%CI,1.225 to 7.317,P<0.05).There was a high correlation between POI and DOI of OSCC.Conclusion DOI≥5 mm is considered as a relevant factor for recurrence and poor prognosis of early OSCC.
作者
储伟明
郭爱军
蒋记心
戈杰
薛雨
管玮
CHU Weiming;GUO Aijun;JIANG Jixin;GE Jie;XUE Yu;GUAN Wei(Department of Stomatology,Northern Jiangsu People′s Hospital Affiliated to Yangzhou University,Yangzhou,Jiangsu,225000;Department of Pathology,Northern Jiangsu People′s Hospital Affiliated to Yangzhou University,Yangzhou,Jiangsu,225000;Department of Oral and Maxillofacial Surgery,Changzhou First People′s Hospital,Changzhou,Jiangsu,213000)
出处
《实用临床医药杂志》
CAS
2024年第12期26-30,41,共6页
Journal of Clinical Medicine in Practice
基金
江苏省常州市科技计划项目(应用基础研究)基金资助项目(CJ20220105)。
关键词
口腔鳞状细胞癌
浸润深度
侵袭模式
复发
预后
淋巴结转移
oral squamous cell carcinoma
depth of invasion
pattern of invasion
recurrence
prognosis
lymph node metastasis
