摘要
目的:观察香丹注射液联合常规西药治疗气虚血瘀型冠心病心绞痛患者的效果。方法:选取2021年2月至2023年4月该院收治的78例气虚血瘀型冠心病心绞痛患者进行前瞻性研究,按照随机数字表法将其分为观察组(n=39)和对照组(n=39)。对照组给予常规西药治疗,观察组在对照组基础上增加香丹注射液治疗,比较两组临床疗效、心绞痛发作情况,治疗前后心功能指标[左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)和左心室射血分数(LVEF)]、病情相关指标[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、血管扩张刺激磷蛋白(VASP)、妊娠相关血浆蛋白A(PAPP-A)]水平,以及治疗期间不良反应发生率。结果:观察组治疗总有效率为94.87%(37/39),高于对照组的79.49%(31/39),差异有统计学意义(P<0.05);治疗后,观察组心绞痛发作频率低于对照组,持续时间短于对照组,硝酸甘油用量少于对照组,差异均有统计学意义(P<0.05);治疗后,观察组LVEDD、LVESD水平均低于对照组,LVEF水平高于对照组,差异有统计学意义(P<0.05);治疗后,观察组IL-6、TNF-α和PAPP-A水平均低于对照组,VASP水平高于对照组,差异有统计学意义(P<0.05);治疗期间,两组均未发生明显不良反应。结论:香丹注射液联合常规西药治疗气虚血瘀型冠心病心绞痛患者可提高治疗总有效率,改善心绞痛发作情况、心功能指标水平和病情相关指标水平,效果优于常规西药治疗。
Objective:To observe effects of Xiangdan injection combined with conventional Western medicine in treatment of patients with angina pectoris of coronary heart disease of qi deficiency and blood stasis type.Methods:A prospective study was conducted on 78 patients with angina pectoris of coronary heart disease of qi deficiency and blood stasis type admitted to the hospital from February 2021 to April 2023.According to the random number table method,they were divided into observation group(n=39)and control group(n=39).The control group was treated with conventional Western medicine,while the observation group was treated with Xiangdan injection on the basis of that of the control group.The clinical efficacy,the angina pectoris attack,the levels of cardiac function indexes[left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)and left ventricular ejection fraction(LVEF)]and the disease-related indexes[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),vasodilator-stimulated phosphoprotein(VASP),pregnancy-associated plasma protein A(PAPP-A)]levels before and after the treatment,and the incidence of adverse reactions during treatment were compared between the two groups.Results:The total effective rate of the observation group was 94.87%(37/39),which was higher than 79.49%(31/39)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the frequency of angina pectoris in the observation group was lower than that in the control group,the duration was shorter than that in the control group,the dosage of Nitroglycerin was less than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of LVEDD and LVESD in the observation group were lower than those in the control group,the level of LVEF was higher than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,TNF-αand PAPP-A in the observation group were lower than those in the control group,the VASP level was higher than that in the control group,and the differences were statistically significant(P<0.05).During the treatment,no obvious adverse reactions occurred in the two groups.Conclusions:Xiangdan injection combined with conventional Western medicine can improve the total effective rate of treatment,improve the attack of angina pectoris,the levels of cardiac function indexes and the levels of disease related indexes in the patients with angina pectoris of coronary heart disease of qi deficiency and blood stasis type.Moreover,it is superior to conventional Western medicine treatment.
作者
夏振华
滕伟
翟小菊
王进
孟祥旭
XIA Zhenhua;TENG Wei;ZHAI Xiaoju;WANG Jin;MENG Xiangxu(Department of Cardiology of the First Affiliated Hospital of Henan University,Kaifeng 475000 Henan,China)
出处
《中国民康医学》
2024年第15期98-101,共4页
Medical Journal of Chinese People’s Health
基金
河南省医学科技攻关计划联合共建项目(LHGJ20200554)。
关键词
香丹注射液
气虚血瘀型
冠心病
心绞痛
心功能
不良反应
Xiangdan injection
Qi deficiency and blood stasis type
Coronary heart disease
Angina pectoris
Cardiac function
Adverse reaction
