摘要
目的分析不同剂量重组人生长激素(rhGH)对特发性矮小症(ISS)患儿25-羟维生素D、胰岛素样生长因子1(IGF-1)水平的影响。方法选取2019年12月至2021年7月在山东大学附属儿童医院儿童保健所就诊的ISS儿童共72例为研究对象。患儿均在常规营养支持治疗基础上给予rhGH治疗,根据rhGH的剂量不同分为两组,对照组(34例)的剂量为0.15IU/(kg·d),观察组(38例)的剂量为0.20 IU/(kg·d),比较两组身高、身高标准差积分(HtSDS)、体重指数(BMI)及治疗后25-羟维生素D、IGF-1水平的变化。结果两组治疗前身高、HtSDS、BMI、25-羟维生素D、IGF-1水平比较,差异无统计学意义(P>0.05);治疗后,观察组HtSDS、IGF-1水平均高于对照组(P<0.05)。结论高剂量rhGH可有效改善ISS儿童的身高及IGF-1水平,值得临床应用。
Objective To analyze the effect of different doses of Recombinant Human Growth Hormone(rhGH)on 25-hydroxyvitamin D and insulin-like growth factor 1(IGF-1)levels in children with idiopathic short stature(ISS).Methods A total of 72 children with ISS in Children’s Health Center,Children’s Hospital Affiliated to Shandong University from December 2019 to July 2021 were enrolled.All the children received rhGH treatment based on conventional nutritional support.According to the different doses of rhGH,they were divided into two groups,the dose of control group(34 cases)was 0.15 IU/(kg·d),and the dose of observation group(38 cases)was 0.20 IU/(kg·d).The changes of height,height-standard deviation score(HtSDS),body mass index(BMI),and 25-hydroxyvitamin D and IGF-1 levels were compared between the two groups.Results There were no significant differences in height,HtSDS,BMI,and levels of 25-hydroxyvitamin D and IGF-1 between the two groups before treatment(P>0.05).After treatment,the HtSDS and IGF-1 level in the observation group were higher than those in the control group(P<0.05).Conclusion High-dose rhGH can effectively improve the height and IGF-1 level in ISS children,which is worthy of clinical application.
作者
吴伟
陈飞
由庆云
徐卫芳
李宁
WU Wei;CHEN Fei;YOU Qingyun;XU Weifang;LI Ning(Children’s Health Center,Children’s Hospital Affiliated to Shandong University,Jinan Children’s Hospital,Shandong Province,Jinan 250000,China;Department of Pediatrics,Linqing People’s Hospital,Shandong Province,Linqing 252600,China;Department of Child Health,Feixian Maternal and Child Healthcare Hospital of Linyi,Shandong Province,Linyi 273400,China)
出处
《妇儿健康导刊》
2024年第14期60-63,共4页
JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE
