摘要
目的探究平肝定眩合剂联合针灸对肝阳上亢型后循环缺血(posterior circulatory ischemia,PCI)患者的治疗疗效。方法2020年6月—2022年6月期间,在该院随机选取肝阳上亢型PCI患者90例,采用随机数表法分为观察组(45例)和对照组(45例)。对照组患者采用针灸治疗,观察组在其基础上联合平肝定眩合剂治疗,对比两组的治疗疗效、不良反应以及血清纤维蛋白原(fibrinogen,FIB)、肌酐(creatinine,Cr)、谷丙转氨酶(alanine aminotransferase,ALT)变化,同时对患者进行经颅多普勒超声(TCD)检查。结果两组患者的治疗总有效率、不良反应发生率差异无统计学意义(P>0.05)。治疗后,观察组患者血清FIB浓度低于对照组(P<0.05),左/右侧椎动脉和基底动脉的平均血流速度(Vm)高于对照组(P<0.05)。治疗后,两组血清两组血清Cr、ALT差异无统计学意义(P>0.05),两组间差异无统计学意义(P>0.05)。结论平肝定眩合剂联合针灸、单行针灸治疗均对肝阳上亢型PCI具有一定的治疗疗效,然而联合治疗对患者的大脑血供以及脑细胞的积极影响更为显著,且具有一定的安全性,值得临床重视。
Objective To explore the therapeutic effect of Pinggan Dingxuan Mixture(平肝定眩合剂)combined with acupuncture on patients with hyperactive liver-Yang posterior circulatory ischemia(PCI).Methods Between June 2020 and June 2022,90 patients with hyperactive liver-Yang PCI were randomly selected in the hospital and divided into observation group(45 cases)and control group(45 cases)by random number table method.The control group was treated with acupuncture,and the observation group was treated with Pinggan Dingxuan Mixture on the basis of acupuncture.The therapeutic efficacy,adverse reactions and the changes of serum fibrinogen(FIB),creatinine(Cr)and alanine aminotransferase(ALT)of the two groups were compared.At the same time,the patients were examined by transcranial Doppler ultrasound(TCD).Results There was no difference in the total effective rate and incidence of adverse reactions between two groups(P>0.05).After treatment,the serum FIB concentration in the observation group was lower than that in the control group(P<0.05),and the average blood flow velocity(Vm)in left、right vertebral arteries and basilar artery was higher than that in control group(P<0.05).After treatment,there were no significant changes in serum Cr and ALT between the two groups(P>0.05),and there was no statistical significance between the two groups(P>0.05).Conclusion Pinggan Dingxuan Mixture combined acupuncture and single acupuncture treatment have certain therapeutic effects on hyperactive liver-Yang type PCI,but the combined therapy has more significant positive effects on cerebral blood supply and brain cells of patients,and has certain safety,worthy of clinical attention.
作者
郑中花
田黎
臧修明
户稼庆
ZHENG Zhonghua;TIAN Li;ZANG Xiuming;HU Jiaqing(Department of Internal Medicine,Pizhou Hospital of Traditional Chinese Medicine,Xuzhou 221300,Jiangsu,China)
出处
《辽宁中医杂志》
CAS
北大核心
2024年第8期99-102,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
徐州市中医药科技发展计划项目(XZYB2021028)。
关键词
肝阳上亢型后循环缺血
平肝定眩合剂
针灸
基底动脉血流
hyperactive liver-Yang posterior circulation ischemia
Pinggan Dingxuan Mixture(平肝定眩合剂)
acupuncture
basilar blood flow
