摘要
目的探讨子宫肌瘤患者血清糖类抗原(CA)125、CA199、人附睾蛋白(HE)4表达水平及与其术后转归的相关性。方法选取子宫肌瘤患者93例,均行腹腔镜子宫肌瘤剔除术,于术后12个月行超声检查,观察子宫肌瘤复发情况,收集入组患者一般临床资料,并于术前、术后1个月分别检测患者血清CA125、CA199、HE4表达水平,分析影响复发的因素,并采用受试者工作特征曲线(ROC)分析血清学指标对术后复发的评估价值。结果截止于随访终点,93例子宫肌瘤患者中15例复发,复发率为16.13%。复发组和未复发组在年龄、身体体质量指数、肌瘤位置、分娩史和术前血清CA199、CA125、HE4水平方面比较无差异(P>0.05);复发组最大肌瘤直径>10 cm、多发肌瘤数目、初潮年龄≤13岁的占比高于未复发组(P<0.05);复发组术后1个月的血清CA199、CA125、HE4水平高于未复发组(P<0.05)。Logistic回归分析显示,最大肌瘤直径和术后1个月血清CA199、CA125、HE4水平均为影响子宫肌瘤患者术后复发的独立因素(OR=6.334、7.486、7.345、8.423,P<0.05)。ROC结果显示,术后1个月血清CA199、CA125、HE4水平评估术后复发的AUC分别为0.834、0.836和0.846。结论子宫肌瘤患者血清CA125、CA199、HE4表达水平与术后复发有关,可作为术后转归评估的辅助性指标。
Objective To explore the expression levels of serum carbohydrate antigen(CA)125,CA199 and human epididymal protein(HE)4 in patients with uterine fibroid and their correlation with postoperative outcomes.Methods A total of 93 patients with uterine fibroid undergoing laparoscopic myomectomy were enrolled.All underwent ultrasound examination at 12 months after surgery to observe the recurrence of uterine fibroid.The general clinical data of patients were collected.The expression levels of serum CA125,CA199 and HE4 were detected before surgery and at 1 month after surgery.The influencing factors of recurrence were analyzed,and the evaluation value of serological indexes for postoperative recurrence was analyzed by receiver operating characteristic(ROC)curves.Results By the end of follow-up,there were 15 recurrence cases(16.13%)in the 93 patients with uterine fibroid.There was no significant difference in age,body mass index,fibroid sites,delivery history and preoperative levels of serum CA199,CA125 and HE4 between recurrence group and non-recurrence group(P>0.05).The proportions of the maximum fibroid diameter>10cm,number of multiple fibroids and menarche age≤13 years in recurrence group were higher than those in non-recurrence group(P<0.05),and levels of serum CA199,CA125 and HE4 were higher than those in non-recurrence group at 1 month after surgery(P<0.05).Logistic regression analysis showed that maximum fibroid diameter and levels of serum CA199,CA125 and HE4 at 1 month after surgery were independent influencing factors of postoperative recurrence in patients with uterine fibroid(OR=6.334,7.486,7.345,8.423,P<0.05).The results of ROC curves analysis showed that AUC values of serum CA199,CA125 and HE4 at 1 month after surgery for evaluating postoperative recurrence were 0.834,0.836 and 0.846,respectively.Conclusion The expression levels of serum CA125,CA199 and HE4 are correlated with postoperative recurrence in patients with uterine fibroid,which can be applied as auxiliary evaluation indexes for postoperative outcomes.
作者
王玉霞
吴坤英
张苗苗
林雁
WANG Yuxia;WU Kunying;ZHANG Miaomiao(Zhengzhou Maternal and Child Health Hospital Zhengzhou,Zhengzhou,450000)
出处
《实用癌症杂志》
2024年第9期1419-1422,1427,共5页
The Practical Journal of Cancer
关键词
子宫肌瘤
糖类抗原199
糖类抗原125
人附睾蛋白4
复发
Uterine fibroid
Carbohydrate antigen 199
Carbohydrate antigen 125
Human epididymal protein 4
Recurrence
