摘要
目的:分析伊伐布雷定联合沙库巴曲缬沙坦治疗心力衰竭合并高血压的效果。方法:选取2021年1月—2023年1月就诊于我院的126例心力衰竭合并高血压患者分为单药组、联合组,各63例。联合组在单药组的基础上联合使用伊伐布雷定治疗,单药组使用沙库巴曲缬沙治疗,比较两组心功能、血压水平、成纤维细胞生长因子2(FGF2)、羟基二十碳四烯酸(HETEs)、白介素-6(IL-6)、五聚蛋白3(PTX3)及不良反应发生率、临床疗效。结果:两组治疗后左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)水平低于治疗前,左室射血分数(LEVF)水平高于治疗前,且联合组优于单药组(P<0.05);两组治疗后IL-6、HETEs水平低于治疗前,且联合组优于单药组(P<0.05);两组治疗后舒张压、收缩压水平低于治疗前,且联合组优于单药组(P<0.05);两组治疗后FGF2、PTX3水平低于治疗前,且联合组优于单药组(P<0.05);联合组治疗总有效率高于单药组(P<0.05);联合组不良反应发生率高于单药组,但差异无统计学意义(P>0.05)。结论:伊伐布雷定辅以沙库巴曲缬沙坦治疗可改善心力衰竭合并高血压患者血压水平,促进心功能恢复,效果理想。
Objective:To analyze the effect of ivabradine combined with sacubitril valsartan in the treatment of heart failure complicated with hypertension.Methods:A total of 126 patients with heart failure combined with hypertension admitted to our hospital from January 2021 to January 2023 were divided into single drug group and combined group,with 63 patients in each group.The combined group was treated with ivabradine on the basis of the single drug group,and the single drug group was treated with sacubactrivalsa.Cardiac function,blood pressure,fibroblast growth factor 2(FGF2),hydroxy eicosatetraenoic acid(HETEs),interleukin-6(IL-6),pentamerin 3(PTX3),incidence of adverse reactions and clinical efficacy were compared between the two groups.Results:The levels of left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)after treatment were lower than before treatment,and the level of left ventricular ejection fraction(LEVF)was higher than before treatment,and those in the combined group were better than those in the single drug group(P<0.05).The levels of IL-6 and HETEs after treatment were lower than before treatment,and those in the combined group were better than those in the single drug group(P<0.05).The levels of diastolic blood pressure and systolic blood pressure after treatment were lower than before treatment,and those in the combined group were better than those in the single drug group(P<0.05).The levels of FGF2 and PTX3 after treatment were lower than before treatment,and those in the combined group were better than those in the single drug group(P<0.05).The total effective rate of combined group was higher than that of single drug group(P<0.05).The incidence of adverse reactions in combined group was higher than that in single drug group,but the difference was not statistically significant(P>0.05).Conclusion:Ivabradine combined with sacubactril valsartan can improve the blood pressure of patients with heart failure complicated with hypertension,and promote therecovery of cardiac function,with ideal effect.
作者
张怡
段宏
唐莉
冯战胜
王永伟
ZHANG Yi;DUAN Hong;TANG Li;FENG Zhansheng;WANG Yongwei(Department of Hypertension,Xihua County People's Hospital,Xihua 466600,Henan,China;Department of Cardiology,Xihua County People's Hospital,Xihua 466600,Henan,China)
出处
《中国药物滥用防治杂志》
CAS
2024年第7期1283-1287,共5页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
伊伐布雷定
沙库巴曲缬沙坦
心力衰竭
高血压
降压
心功能
Ivabradine
Sacubatrol valsartan
Heart failure
High blood pressure
Reduce pressure
Cardiac function
