摘要
目的探讨对妊娠期糖尿病合并亚临床甲状腺功能减退患者实施维生素D治疗的临床效果。方法按照随机数表法将滨州市中心医院自2021年3月至2023年2月收治的妊娠期糖尿病合并亚临床甲状腺功能减退患者90例进行分组,每组各45例,对照组实施基础治疗,观察组加用维生素D治疗,两组均连续治疗1个月,比较两组血糖及甲状腺功能指标、统计两组不良妊娠结局发病率。结果观察组治疗后与对照组治疗后比较,空腹血糖、餐后2 h血糖、糖基化血红蛋白及不良妊娠结局发生率均较低;观察组治疗后与对照组治疗后比较,促甲状腺激素较低、甲状腺素、25-羟基维生素D2及血清钙离子均较高,差异有统计学意义(P<0.05)。结论对妊娠期糖尿病合并亚临床甲状腺功能减退患者实施补充维生素D治疗可促进调整血糖以及甲状腺功能指标,不良妊娠结局风险相对降低,预后表现好。
Objective To investigate the clinical effects of vitamin D treatment in patients with gestational diabetes mellitus(GDM)complicated by subclinical hypothyroidism.Methods A total of 90 patients with GDM complicated by subclinical hypothyroidism admitted to Binzhou Central Hospital from March 2021 to February 2023 were randomly divided into two groups,with 45 patients in each group.The control group received basic treatment,while the observation group received vitamin D treatment in addition to the basic treatment.Both groups were treated continuously for one month.Blood glucose and thyroid function indicators were compared between the two groups,and the incidence of adverse pregnancy outcomes was statistically analyzed.Results After treatment,the observation group had significantly lower levels of fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin,and incidence of adverse pregnancy outcomes compared to the control group.The observation group also had significantly lower levels of thyroid-stimulating hormone and higher levels of thyroxine,25-hydroxyvitamin D2,and serum calcium ions compared to the control group,with statistically significant differences(P<0.05).Conclusion Vitamin D supplementation in patients with gestational diabetes mellitus complicated by subclinical hypothyroidism can help regulate blood glucose and thyroid function indicators,reduce the risk of adverse pregnancy outcomes,and improve prognosis.
作者
赵慧
庞丽
王令令
高爱滨
ZHAO Hui;PANG Li;WANG Lingling;GAO Aibin(Department of Endocrinology,Binzhou Central Hospital,Shandong,Binzhou 251700,China;Department of General Medicine,Binzhou People’s Hospital,Shandong,Binzhou 256600,China)
出处
《中国医药科学》
2024年第14期163-166,共4页
China Medicine And Pharmacy
