摘要
目的分析磁共振成像(M R I)多序列扫描结合血清鳞状细胞癌抗原(S CC A)、糖类抗原153(CA153)、血管内皮生长因子(VEGF)对宫颈癌的诊断价值及对预后的评估价值。方法以2016年6月至2020年6月本院收治的269例宫颈癌患者(恶性组)为研究对象,另选取同期经病理学诊断证实为宫颈良性病变患者120例作为良性组,同时以出院后3年内复发情况为终点将宫颈癌患者分为复发组(n=40)及未复发组(n=229)。所有患者均在入院后行MRI动态增强成像(DCE)及扩散加权成像(DWI)检查,获取定量参数;均测定血清SCCA、CA153、VEGF水平。以受试者特征工作曲线(ROC)分析MRI多序列扫描参数结合血清SCCA、CA153、VEGF对宫颈癌的诊断价值及对预后的评估价值。结果恶性组的ADC值低于良性组,容积转运常数(K^(trans))、速率常数(Kep)、血管外细胞外间隙容积比(Ve)及血清SCCA、CA153、VEGF水平高于良性组(P<0.05);复发组的ADC值低于未复发组,K^(trans)、Kep、Ve及血清SCCA、CA153、VEGF水平高于未复发组(P<0.05)。ROC曲线分析结果显示,MRI多序列扫描参数联合血清SCCA、CA153、VEGF评估宫颈癌的曲线下面积(AUC)为0.971,灵敏度为94.1%%,特异性为93.2%;MRI多序列扫描参数联合血清SCCA、CA153、VEGF评估宫颈癌患者预后的AUC为0.938,灵敏度为93.0%,特异性为80.6%,联合评估的效能均优于各指标单独评估。结论MRI多序列扫描参数、血清SCCA、CA153、VEGF对宫颈癌的诊断及预后评估均具有一定的价值,且MRI多序列扫描参数结合血清学指标可显著提升其诊断效能。
Objective To analyze the value of magnetic resonance imaging(MRI)multi-sequence scan combined with serum squamous-cell cancer cancer(SCCA),glycan 153(CA153),and vasodilular growth factor(VEGF)in the diagnosis and prognosis of cervical cancer.Methods A total of 269 patients with cervical cancer(malignant group)admitted to our hospital from June 2016 to June 2020 were selected as the research objects,and 120 patients with benign cervical lesions confirmed by pathological diagnosis during the same period were selected as the benign group.At the same time,the patients with cervical cancer were divided into relapse group(n=40)and non-relapse group(n=229)based on the relapse within 3 years after discharge.All the patients underwent dynamic contrast-enhanced MRI(DCE-MRI)and diffuse weighted-MRI(DWI-MRI)to obtain quantitative parameters.The levels of SCCA,CA153,and VEGF in the blood were determined.The receiver operating characteristic curve(ROC)was used to analyze the value of MRI multi-sequence scanning parameters combined with serum SCTA,CA153,and VEGF in the diagnosis and prognosis of cervical cancer.Results The ADC value of the malignant group was lower than that of the benign group,but the volume transport constant(K^(trans)),the rate constant(Kep),the ratio of the extravasated space(Ve),and the levels of SCTA,CA153,and VEGF in the serum of the malignant group were higher than those of the benign group(P<0.05).The ADC value of the relapse group was lower than that of the non-relapse group,and the levels of K^(trans),Kep,Ve,and serum SCCA,CA153,and VEGF were higher than those of the non-relapse group(P<0.05).The results of the ROC curve analysis showed that the area under the curve(AUC)of MRI multi-sequence scanning parameters combined with serum SCCA,CA153,and VEGF in evaluating cervical cancer was 0.971,the sensitivity was 94.1%,and the specialty was 93.2%.MRI multi-sequence scan parameters combined with serum SCCA,CA153,and VEGF for evaluating the prognosis of cervical cancer patients had an AUC of 0.938,a sensitivity of 93.0%,and a specialty of 80.6%.The combined evaluation was superior to the individual evaluation of each index.Conclusion The results showed that the parameters of MRI multi-sequence scanning,serum SCCA,CA153,and VEGF were of certain value in the diagnosis and prognosis of cervical cancer.Moreover,the parameters of MRI multi-sequence scanning combined with serological indicators could significantly improve the diagnosis efficiency.
作者
董琳琳
尤云峰
陈乐乐
李娜娜
DONG Lin-lin;YOU Yun-feng;CHEN Le-le;LI Na-na(Clinical Medicine School of Henan University of Science and Technology,Luoyang 471000,Henan Province,China;Department of Imaging,The Third Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan Province,China;Department of Oncology,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan Province,China;Department of Clinical Laboratory,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan Province,China)
出处
《中国CT和MRI杂志》
2024年第8期100-102,173,共4页
Chinese Journal of CT and MRI
基金
河南省医学科技攻关计划项目(201601143)。
