摘要
目的:分析对老年冠心病患者应用阿司匹林和氯吡格雷治疗后睡眠质量的影响。方法:选取2022年1月至2023年1月平凉市静宁县人民医院心内科收治的老年冠心病患者100例作为研究对象,按照电脑抽签法分为对照组和观察组,每组50例。对照组采用阿司匹林治疗,观察组采用阿司匹林联合氯吡格雷治疗,观察疗效、睡眠质量、炎症介质及不良反应。结果:对照组疗效为84%,不良反应发生率为10%,观察组分别为98%和4%,对照组疗效低于观察组,不良反应发生率高于对照组,差异有统计学意义(P<0.05);治疗前,2组患者睡眠质量及炎症介质比较,差异无统计学意义(P>0.05),治疗后,观察组指标优于对照组,差异有统计学意义(P<0.05)。结论:应用阿司匹林联合氯吡格雷进行治疗,可提升疗效,改善老年冠心病患者的睡眠质量及炎症指标,同时不良反应未出现变化,可推广。
Objective:To analyze the effects of aspirin and clopidogrel on sleep quality in elderly patients with coronary heart disease.Methods:A total of 100 elderly patients with coronary heart disease enrolled in our hospital during 2022.1 to 2023.1 were divided into the control group(n=50,aspirin)and the study group(n=50,aspirin combined with clopidogrel)by computer lottery method,and the efficacy,sleep quality,inflammatory factors and adverse reactions were observed.Results:The efficacy of the control group was 84%,and the incidence of adverse reactions was 10%,and the study group was 98%and 4%,respectively.The efficacy of the control group was lower than that of the study group,and the data difference was statistically significant(P<0.05).The incidence of adverse reactions was higher in the observed group than in the control group(P<0.05).Before treatment,there was no statistical difference in sleep quality and inflammatory factors(P>0.05).After treatment,the indicators of the study group were better than control group,and the data differences were statistically significant(P<0.05).Conclusion:Aspirin combined with clopidogrel can improve the therapeutic effect,improve the sleep quality and inflammatory indicators of elderly patients with coronary heart disease,and the adverse reactions do not change,which can be promoted.
作者
高旭皓
GAO Xuhao(Department of Cardiology,Jingning County People′s Hospital,Pingliang City,Jingning 743400,China)
出处
《世界睡眠医学杂志》
2024年第6期1252-1254,共3页
World Journal of Sleep Medicine
基金
甘肃省科技型中小企业技术创新基金项目(22CX3GA012)。
关键词
阿司匹林
氯吡格雷
老年冠心病
睡眠质量
炎症介质
不良反应
疗效观察
数据差异
Aspirin
Clopidogrel
Elderly coronary heart disease
Sleep quality
Inflammatory factors
Adverse reactions
Curative effect observation
Data differences
