摘要
特应性皮炎(atopic dermatitis,AD)是一种具有遗传倾向的慢性复发性炎症性皮肤病,常伴过敏性鼻炎、过敏性哮喘以及过敏性结膜炎等炎症性共病。典型临床特征为皮肤干燥、剧烈瘙痒以及反复湿疹样改变。AD的发病可能与遗传、自身免疫反应、外界致敏原、皮肤屏障破坏以及皮肤微生态改变等各种病理生理机制相关。目前,在基因组学、转录组学、蛋白质组学、表观遗传学、宏基因组学及代谢组学等方面,已发现一些具有参考价值的AD生物标志物和潜在靶点,本文将对各组学技术在AD领域的研究进展进行阐述。
Atopic dermatitis(AD)is one kind of chronic relapsing inflammatory skin disease with genetic predisposition and concomitant inflammatory comorbidities such as allergic rhinitis,allergic asthma and allergic conjunctivitis.Typical clinical features included dryness of skin,severe pruritus and recurrent eczema-like lesions.Pathogenesis of AD may be related to various pathophysiological mechanisms such as genetics,autoimmune reaction,external allergens,damage of skin barrier and alternations of skin microecology.At present,reference value of some biomarkers and potential targets was demonstrated among AD,based on the research results of genomics,transcriptomics,proteomics,epigenetics,metagenomics and metabolomics.Progress on research of multi-omics technology in AD was reviewed in this article.
作者
李艳飞
李旭
李丹
佟鑫
李娇娇
张俊晶
LI Yanfei;LI Xu;LI Dan;TONG Xin;LI Jiaojiao;ZHANG Junjing(Department of Dermatology&STD,Department of Allergy,Hohhot First Hospital,Hohhot 010030,China;Hohhot Allergy Center,Department of Allergy,Hohhot First Hospital,Hohhot 010030,China;Department of Allergy,Hohhot First Hospital,Hohhot 010030,China)
出处
《中华临床免疫和变态反应杂志》
CAS
2024年第4期407-414,共8页
Chinese Journal of Allergy & Clinical Immunology
基金
内蒙地区儿童特应性皮炎的皮肤微生态和脂质组学研究(202201480)
致敏SP和PM通过BDNF促进TJs转录调控特应性皮炎皮肤屏障瘙痒机制的研究(2022SYY082)
呼和浩特市卫生健康领域科技项目(呼卫健医疗-2023015)
呼和浩特市第一医院院内项目[2021SYY(ZD)01]。
