摘要
目的分析术前、术后癌胚抗原(CEA)差值对胃癌患者腹腔镜辅助远端胃癌根治术(LADG)后复发的影响。方法前瞻性分析,纳入2020年1月至2021年6月安阳市人民医院收治的110例接受LADG治疗的胃癌患者为研究对象,随访2 a,根据2 a内复发情况分为复发组和未复发组。收集患者临床资料及术前1 d、术后1个月血清CEA水平,并计算其差值,分析CEA差值对胃癌患者LADG术后复发的影响。结果110例胃癌患者LADG术后2 a复发41例(37.27%);复发组TNM分期Ⅲ期患者占比高于未复发者(P<0.05);两组患者术前CEA比较,差异无统计学意义(P>0.05),复发组术后CEA、CEA差值高于未复发组(P<0.05);经点二列相关性分析,CEA差值与胃癌患者LADG术后复发呈负相关(r=-0.369,P<0.01);绘制受试者工作特征(ROC)曲线,结果显示,CEA差值预测LADG术后复发的曲线下面积(AUC)为0.715,具有一定预测价值。结论胃癌患者LADG术后复发情况与术前、术后血清CEA差值存在密切关系,术前、术后血清CEA差值对患者术后复发具有一定预测价值。
Objective To analyze the effect of preoperative and postoperative carcinoembryonic antigen(CEA)difference on recurrence of gastric cancer patients undergoing laparoscopy-assisted distal gastrectomy(LADG).Methods This study used a prospective analysis to include 110 gastric cancer patients treated with LADG at the People's Hospital of Anyang from January 2020 to June 2021 as the study subjects.They were followed up for 2 years and divided into recurrence group and non-recurrence group based on their recurrence within 2 years.The clinical data of the patients and the serum CEA levels at 1 day before operation and 1 month after operation were collected,and the difference was calculated to analyze the effect of CEA difference on the recurrence of LADG in patients with gastric cancer.Results Among 110 gastric cancer patients,41(37.27%)cases had recurrence 2 years after LADG surgery.The proportion of TNM stageⅢpatients in the recurrence group was higher than that without recurrence(P<0.05).There was no statistical difference in preoperative CEA between the two groups(P>0.05).Postoperative CEA and CEA difference in the recurrence group were higher than those in the non-recurrence group(P<0.05).Through point two column correlation analysis,the difference in preoperative and postoperative CEA was negatively correlated with postoperative recurrence of LADG in gastric cancer patients(r=-0.369,P<0.01).The receiver operating characteristic(ROC)curve was drawn.The results showed that the area under the curve(AUC)of CEA difference for predicting recurrence after thoracoscopic radical resection of lung cancer was 0.715,which had certain predictive value.Conclusion There is a close relationship between the postoperative recurrence of LADG in gastric cancer patients and the difference in serum CEA before and after surgery.The difference in serum CEA before and after surgery has certain predictive value for the postoperative recurrence of patients.
作者
卢云锋
王志军
LU Yunfeng;WANG Zhijun(Department of Gastrointestinal Surgery,the People’s Hospital of Anyang,Anyang 455000,China)
出处
《河南医学研究》
CAS
2024年第16期2958-2961,共4页
Henan Medical Research
关键词
胃癌
腹腔镜辅助远端胃癌根治术
癌胚抗原
复发
gastric cancer
laparoscopy-assisted distal gastrectomy
carcinoembryonic antigen
recurrence
