摘要
成年哺乳动物心肌细胞在出生后迅速退出细胞周期,当心肌细胞因缺血或其他因素而损伤,残留存活的心肌细胞增殖能力十分有限,取而代之的是不具有收缩能力的纤维组织,从而引发不良心脏重构,最终导致心力衰竭。为了改善心力衰竭患者的预后,开发根本有效的治疗策略至关重要。目前研究已通过多种方法和模型来实现心肌细胞的再生,现综述实现心脏再生方法的研究现状,旨在阐明各种操纵心脏再生和促进心脏损伤后修复的策略,并讨论未来临床应用的前景和挑战。
Adult mammalian cardiomyocytes rapidly withdraw from the cell cycle after birth,When cardiomyocytes are injured by ischemia or other factors,the proliferation ability of surviving cardiomyocytes is very limited,and they are replaced by fibrous tissue without contractile ability,which causes adverse cardiac remodeling and ultimately leads to heart failure.In order to improve the prognosis of heart failure patients,it is crucial to develop fundamentally effective treatment strategies.At present,many methods and models have been used to realize the regeneration of cardiomyocytes.This review summarizes the research status of the methods of heart regeneration,aims to clarify various strategies for manipulating heart regeneration and promoting repair after heart injury,and discusses the prospects and challenges of clinical application in the future.
作者
张莉
熊峰
ZHANG Li;XIONG Feng(Department of Cardiology,The Affiliated Hospital of Southwest Jiao Tong University,The Third People’s Hospital of Chengdu,Cardiovascular Disease Research Institute of Chengdu,Chengdu 610031,Sichuan,China)
出处
《心血管病学进展》
CAS
2024年第8期727-731,共5页
Advances in Cardiovascular Diseases
基金
国家自然科学基金(82270486)
四川省自然科学基金(24NSFSC0262)。
关键词
心脏再生
多能干细胞
再生医学
重编程
Cardiac regeneration
Pluripotent stem cell
Regenerative medicine
Reprogramming
