摘要
目的:探讨肿瘤特异性生长因子(TSGF)与急性加重期慢性阻塞性肺疾病(AECOPD)严重程度的关系。方法:回顾性分析100例AECOPD患者的临床资料和血液指标结果,根据肺功能GOLD分级标准将100例AECOPD患者分为非严重组和严重组。检测患者血清TSGF、超敏C反应蛋白(hs-CRP)、D-二聚体(D-D)、白细胞(WBC)、血小板(PLT)、中性粒细胞(N)、红细胞分布宽度(RDW)、淋巴细胞计数(L)和纤维蛋白原(FIB);采用Pearson相关和Spearman相关分析TSGF与其他指标间的相关性,Logistic回归分析TSGF与AECOPD严重程度间的相关性,ROC曲线分析TSGF在AECOPD诊断中的预测效能。结果:严重组AECOPD患者的TSGF水平高于非严重组(P<0.05);TSGF与hs-CRP、FIB及RDW呈正相关(P<0.05);高TSGF与AECOPD加重风险相关(OR=1.391,95%CI:1.210~1.599,P<0.001);TSGF预测AECOPD严重程度的ROC曲线下面积(AUC)为0.920(95%CI:0.848~0.965,P<0.001),Cut-off值为65.5,灵敏度为96.00%,特异度为90.00%。结论:TSGF可能是新的预测AECOPD严重程度的标志物。
Objective:To investigate the correlation between tumor-specific growth factor(TSGF)and the severity of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:Retrospective analysis was conducted on the clinical data and laboratory findings in 100 patients with AECOPD.The cases were divided into non-severe group and severe group by the GOLD classification.The automatic biochemical analyzer 008AS of HITACHI,automatic blood cell analyzerXN1001 and automatic blood coagulation analyzer CS-5100 of SYSMEX were used to detect serum TSGF,hypersensitive C-reactive protein(hs-CRP),D-Dimer(D-D),white blood cell(WBC)count,platelet count(PLT),neutrophil(N)count,red blood cell distribution width(RDW),lymphocyte(L)count and fibrinogen(FIB).Pearson and Spearman correlation was used to analyze the correlation of TSGF with NLR,hs-CRP,FIB and RDW,While logistic regression was performed to analyze the correlation between TSGF and other indicators and the severity of AECOPD,respectively.The predictive efficacy of TSGF in the diagnosis severity of AECOPD was evaluated by comparing the area under the curve(AUC)of ROC curve.Results:TSGF in patients of severe group was significantly higher than that in those of non-severe group(P<0.05),and positively correlated with hs-CRP,FIB and RDW(P<0.05).Higher TSGF was significantly correlated with severity of AECOPD(OR=1.391,95%CI:1.210-1.599,P<0.001);The area of ROC curve was 0.920 in predicting the severity of patient with AECOPD(95%CI:0.848~0.965,P<0.001)and the cut-off value of TSGF was 65.5,with sensitivity being 96%and specificity being 90%.Conclusion:TSGF may be a new biomarker to evaluate the severity of AECOPD.
作者
朱伟
罗兵
冯梅
ZHU Wei;LUO Bing;FENG Mei(Medical Laboratory Center,Anhui No.2 Provincial People′s Hospital,Hefei 230041,Anhui,China)
出处
《皖南医学院学报》
CAS
2024年第4期326-329,共4页
Journal of Wannan Medical College
基金
安徽高校自然科学研究项目(KJ2019A1099)。
