摘要
目的分析不同胰岛素给药方式治疗ICU糖尿病酮症酸中毒的疗效及安全性。方法回顾性选取2023年1月—2024年2月泉州市第一医院收治的98例糖尿病酮症酸中毒患者的临床资料,根据治疗方式的不同分为两组,各49例。对照组胰岛素使用方式为静脉滴注,研究组胰岛素使用方式为皮下泵入,对比两组临床疗效、不良反应(感染、高氯血症、低血糖)、症状改善时间(血糖达标时间、尿酮体转阴时间、血酮体恢复时间)及血糖指标(空腹血糖、餐后2 h血糖、糖化血红蛋白)水平。结果研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。研究组症状改善时间均短于对照组,差异有统计学意义(P均<0.05)。治疗后,研究组血糖水平均低于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论对于ICU糖尿病酮症酸中毒患者,皮下泵入胰岛素治疗是安全、有效、可靠的治疗方法,能够提高临床疗效,降低血糖水平,促进疾病症状缓解,且安全性较高。
Objective To analyze the efficacy and safety of different insulin administration methods in the treatment of diabetic ketoacidosis in ICU.Methods The clinical data of 98 patients with diabetic ketoacidosis admitted to Quan⁃zhou First Hospital from January 2023 to February 2024 were retrospectively selected and divided into two groups ac⁃cording to different treatment methods,with 49 cases in each group.The insulin use in the control group was intrave⁃nous drip,and the insulin use in the study group was subcutaneous pumping.The clinical efficacy,adverse reactions(infection,hyperchloremia,hypoglycemia),symptom improvement time(blood glucose standard time,urine ketone body negative time,blood ketone body recovery time)and blood glucose index(fasting blood glucose,2-hour postpran⁃dial blood glucose,glycated hemoglobin A1c)levels were compared between the two groups.Results The total treat⁃ment effective rate of the study group was higher than that of the control group,and the difference was statistically sig⁃nificant(P<0.05).The improvement time of symptoms in the study group were shorter than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the blood glucose levels of the study group were lower than those of the control group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Subcutaneous insulin pumping is a safe,effective and reliable method for the treatment of ICU patients with diabetic ketoacidosis,which can improve clinical efficacy,reduce blood glucose level,and promote the remission of disease symptoms with high safety.
作者
黄燕玲
黄燕华
许燕茹
HUANG Yanling;HUANG Yanhua;XU Yanru(Quanzhou First Hospital,Quanzhou 362000,Fujian,China;The First Affiliated Hospital of Xiamen University,Xiamen 361022,Fujian,China)
出处
《糖尿病新世界》
2024年第12期187-189,194,共4页
Diabetes New World
