摘要
目的探讨依达拉奉右莰醇联合尿激酶静脉溶栓对急性脑梗死患者治疗效果及其对血清学指标的影响。方法非随机选取首都医科大学附属北京安贞医院南充医院(南充市中心医院)2021年8月—2023年8月收治的92例急性脑梗死患者。按治疗方法分为两组,各46例。对照组采用尿激酶经静脉给药进行溶栓治疗,观察组使用依达拉奉右莰醇和尿激酶联合治疗。比较两组临床疗效、脑血液流变学指标、神经和炎症因子水平、日常生活活动能力及精神状态。结果观察组总有效率为97.83%(45/46),高于对照组的80.43%(37/46),差异有统计学意义(χ^(2)=7.180,P<0.05)。治疗后,观察组脑血液流变学指标、神经因子、炎症因子水平、日常生活活动能力评分、精神状态评分均优于对照组,差异有统计学意义(P均<0.05)。结论依达拉奉右莰醇联合尿激酶静脉溶栓可明显改善急性脑梗死的临床效果,改善脑血液流变学指标,调节神经因子与炎性因子水平,改善患者的日常生活活动能力和精神状态。
Objective To explore the impact of combining edaravone dextrocamphorol with urokinase for intravenous thrombolysis on patients with acute cerebral infarction,and the effect on blood markers.Methods Ninety-two patients with acute cerebral infarction admitted to Nanchong Hospital of Beijing Anzhen Hospital Affiliated to Capital Medical University(Nanchong Central Hospital)from August 2021 to August 2023 were selected nonrandomly.They were divided into two groups according to treatment methods,with 46 cases each.The control group was treated with thrombolysis using urokinase administered intravenously,and the observation group was treated with the combination of edaravone dextran and urokinase.The clinical efficacy,cerebral blood rheology indexes,levels of neurological and inflammatory factors,ability of daily life activities and mental state of the two groups were compared.Results The total effective rate of the observation group was 97.83%(45/46),higher than 80.43%(37/46)of the control group,and the difference was statistically significant(χ^(2)=7.180,P<0.05).After treatment,the cerebral blood rheology indexes,neurofactors,inflammatory factor levels,daily life activity scores,and mental state scores of the observation group were better than those of the control group,and the differences were statistically significant(all P<0.05).Conclusion Dexamfetamine combined with urokinase intravenous thrombolysis of edaravone can significantly improve the clinical outcome of acute cerebral infarction,improve cerebral blood rheology indexes,regulate the levels of neurofactors and inflammatory factors,and improve the ability of patients to perform activities of daily living and mental status.
作者
尹书斌
刘伟
余静梅
YIN Shubin;LIU Wei;YU Jingmei(Department of Neurology,Nanchong Hospital,Beijing Anzhen Hospital Affiliated to Capital Medical University(Nanchong Central Hospital),Nanchong 637000,Sichuan,China;Department of Gastrointestinal Surgery,Jialing District People's Hospital,Nanchong 637000,Sichuan,China)
出处
《系统医学》
2024年第14期95-98,共4页
Systems Medicine
关键词
依达拉奉右莰醇
尿激酶
静脉溶栓
急性脑梗死
血清学指标
Edaravone dextrocamphenol
Urokinase
Intravenous thrombolysis
Acute cerebral infarction
Serological indicators
