摘要
目的分析单光子发射计算机断层显像(single photon emission computed tomography,SPECT)联合声触诊组织量化成像(virtual touch tissue imaging quantification,VTIQ)预测乙型肝炎纤维化患者预后的价值。方法选取嘉兴市第一医院2017年10月至2021年11月乙型肝炎纤维化患者156例作为研究对象,对患者均随访6个月,根据治疗预后分为预后良好组(104例)与预后不良组(52例),均经SPECT首次通过法测定肝血流指数,VTIQ测定剪切波速度(shear wave velocity,SWV),分析比较肝血流指数、SWV值预测乙型肝炎纤维化预后的价值。结果预后不良组肝纤维化程度、Child-Pugh分级高于预后良好组(P<0.05),肝血流指数、SWV值高于预后良好组(t=3.861,P<0.001;t=5.393,P<0.001);多元线性回归分析显示,将其他因素控制后,肝血流指数、SWV与乙型肝炎纤维化预后(肝纤维化弹性指数)独立相关(P<0.05);受试者工作特征曲线(ROC)分析,肝血流指数联合SWV预测乙型肝炎纤维化预后的曲线下面积(AUC)为0.931,95%CI为0.889~0.987,灵敏度为91.80%,特异度为82.10%,较各指标单一预测价值高。结论肝血流指数、SWV与乙型肝炎纤维化程度、Child-Pugh分级显著相关,肝血流指数联合VTIQ预测乙型肝炎纤维化预后具有较高的价值。
Objective To analyze the value of single photon emission computed tomography(SPECT)combined with virtual touch tissue imaging quantification(VTIQ)in predicting the prognosis of patients with hepatitis B fibrosis.Methods A total of 156 patients with hepatitis B fibrosis in the First Hospital of Jiaxing from October 2017 to November 2021 were selected as the research objects.The patients were followed up for 6 months,and they were divided into good prognosis group(104 cases)and poor prognosis group(52 cases)according to the treatment prognosis,all of them were measured by SPECT of the first time to measure the liver blood flow index and VTIQ to measure the shear wave velocity(SWV),analysis of the value of comparing hepatic blood flow index and SWV values to predict the prognosis of hepatitis B fibrosis.Results The degree of liver fibrosis and Child-Pugh classification in the poor prognosis group were higher than those in the good prognosis group(P<0.05),liver blood flow index and SWV were higher than those in the good prognosis group(t=3.861,P<0.001;t=5.393,P<0.001);Multiple linear regression analysis,after controlling for other factors,liver blood flow index,SWV are still independently correlated with the prognosis of hepatitis B fibrosis(liver fibrosis elasticity index)(P<0.05);According to analysis of receiver operating characteristic(ROC)curve,the combination of liver blood flow index and SWV predicts the prognosis of hepatitis B fibrosis with area under the curve(AUC)was 0.931,95%CI was 0.889-0.987,sensitivity was 91.80%,and specificity was 82.10%,higher predictive value than single indicators.Conclusion Liver blood flow index,SWV are significantly related to the degree of hepatitis B hepatic fibrosis and Child-Pugh classification.The combined predicting value of prognosis is reliable and can be used as a potential way to predict prognosis.
作者
刘晓杰
周利杰
冯柳
LIU Xiao-jie;ZHOU Li-jie;FENG Liu(Department of Nuclear Medicine,the First Hospital of Jiaxing,Jiaxing 314000,China;不详)
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2024年第7期580-584,共5页
Chinese Journal of Practical Internal Medicine
基金
嘉兴市医学重点学科项目(2023-ZC-009)
嘉兴市科技计划项目(民生科技创新研究)(2021AY30013)。
关键词
乙型肝炎纤维化
单光子发射计算机断层显像
声触诊组织量化成像
肝血流指数
剪切波速度
hepatitis B fibrosis
single photon emission computed tomography
virtual touch tissue imaging quantificat liver blood flow index
shear wave velocity
