摘要
宿主导向治疗(host-directed therapy,HDT)是一种新的结核病辅助治疗方法,它针对宿主细胞而非病原体,利用调节宿主免疫应答反应来对抗感染。当药物与抗结核药物联合应用时,有助于增强化学药物疗效、缩短治疗时间、改善免疫病理损伤和减少耐药性产生等。笔者综述了结核病HDT候选药物的常见作用机制,并列举了目前正在研究的HDT候选药物,为寻找新型有效的抗结核治疗药物提供参考依据。
Host-directed therapy(HDT)is a new adjuvant therapy for tuberculosis,which aims at host cells rather than pathogens via modulating host immune response to combat infections.When combined use of HDT with anti-tuberculosis drugs,it provides benefits to enhance the efficacy of chemotherapy,shorten the treatment duration,decrease immunopathological damage,and prevent the emergence of drug resistance.This paper reviews the common mechanisms of HDT,and summarizes several HDT drug candidates that are currently being studied,in order to provide new insight for developing new and effective anti-tuberculosis therapies.
作者
闫红璇
袁金锋
王艺霖
逄宇
高孟秋
Yan Hongxuan;Yuan Jinfeng;Wang Yilin;Pang Yu;Gao Mengqiu(DepartmentⅡof Tuberculosis,Beijing Chest Hospital,Capital Medical University,Beijing 101149,China;Department of Bacterial Immunity,Beijing Chest Hospital,Capital Medical University,Beijing 101149,China)
出处
《中国防痨杂志》
CAS
CSCD
北大核心
2024年第10期1273-1282,共10页
Chinese Journal of Antituberculosis
基金
结核病新药靶结构解析及防治新策略和新手段开发(2022YFC2302903)。
关键词
结核
免疫
治疗应用
综述文献(主题)
Tuberculosis
Immunity
Therapeutic uses
Review literature as topic
