摘要
分枝杆菌感染给全球带来了很大的健康负担,尤其是耐多药结核病(MDR-TB)对公共卫生和卫生安全的威胁,寻找一种有效对抗分枝杆菌感染的方法成为亟待解决的问题。分枝杆菌噬菌体是特异性感染分枝杆菌的病毒,可以通过裂解宿主菌导致其死亡。目前,大量的分枝杆菌噬菌体已被分离和完成全基因组测序,可以帮助我们深入了解噬菌体的遗传多样性和基因组结构,并推动其应用和发展。因此,本文综述了分枝杆菌噬菌体基因组学的一般特征及基因功能与表达,以提供分枝杆菌噬菌体治疗新思路。
Mycobacterial infections represent a significant global health burden,with multidrug-resistant tuberculosis(MDR-TB)posing a critical public health crisis and a serious threat to health security.Identifying effective strategies to combat mycobacterial infections has become an urgent priority.Mycobacteriophages,viruses that specifically target and lyse mycobacteria,offer a promising approach by effectively killing the host bacteria.litating the advancement of mycobacteriophage applications.This review explores the general genomic characteristics,gene functions,and expression patterns of mycobacteriophages,offering a foundation for further research in this field.
作者
刘珂君
张海鹏
王鹏
Liu Kejun;Zhang Haipeng;Wang Peng(School of Public Health,Dali University,Dali 671000,China;Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention,Yunnan Institute for Endemic Disease Control and Prevention,Dali 671000,China)
出处
《中国防痨杂志》
CAS
CSCD
北大核心
2024年第10期1283-1292,共10页
Chinese Journal of Antituberculosis
基金
云南省高层次卫生健康技术人才培养专项(No.L-2019001)
云南省产业技术创新人才(YNWR-CYJS-2018-012)。
