摘要
目的分析特发性肺间质纤维化合并营养不良患者预后不良的影响因素。方法选取2019年8月—2023年7月河北省沧州中西医结合医院收治的50例特发性肺间质纤维化合并营养不良患者为研究对象。使用自制调查问卷收集患者的临床资料,内容包括患者的基本信息(性别、年龄、文化程度、工作状况、家庭收入、独立生活情况)、不良生活方式(吸烟、酗酒)、疾病情况(病程、干咳发生情况、胸闷发生情况、急性加重次数)、治疗方式及入院时肺功能指标〔肺总量(TLC)、用力肺活量(FVC)占预计值百分比〕及实验室检查指标〔动脉血氧分压(PaO_(2))、前白蛋白、白蛋白〕、免疫功能情况。特发性肺间质纤维化合并营养不良患者预后不良的影响因素分析采用多因素Logistic回归分析。结果50例特发性肺间质纤维化合并营养不良患者中,预后良好35例、预后不良15例。预后良好者与预后不良者年龄、家庭收入、干咳发生率、胸闷发生率、急性加重次数、治疗方式、TLC占预计值百分比、FVC占预计值百分比、PaO_(2)、前白蛋白、白蛋白及免疫功能比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,年龄≥40岁、家庭收入低、干咳、胸闷、急性加重次数≥1次/月、手术治疗、TLC占预计值百分比<64%、FVC占预计值百分比<70%、PaO_(2)<56 mmHg、前白蛋白<165 mg/L、白蛋白<35 g/L、免疫功能异常是特发性肺间质纤维化合并营养不良患者预后不良的危险因素(P<0.05)。结论年龄≥40岁、家庭收入低、干咳、胸闷、急性加重次数≥1次、手术治疗、TLC占预计值百分比<64%、FVC占预计值百分比<70%、PaO_(2)<56 mmHg、前白蛋白<165 mg/L、白蛋白<35 g/L、免疫功能异常是特发性肺间质纤维化合并营养不良患者预后不良的危险因素。
Objective To analyze the influencing factors of poor prognosis in patients with idiopathic pulmonary interstitial fibrosis complicated with malnutrition.Methods From August 2019 to July 2023,50 patients with idiopathic pulmonary interstitial fibrosis complicated with malnutrition admitted to Cangzhou Hospital of Integrated TCM-WM·Heibei were selected as the research objects.The clinical data of the patients were collected by self-made questionnaire,including the basic formation of the patients(gender,age,education level,working status,family income,independent living conditions),unhealthy lifestyle(smoking,alcohol abuse),disease status(course of disease,occurrence of dry cough,occurrence of chest tightness,number of acute exacerbations),treatment methods and pulmonary function indexes at admission[percentage of total lung capacity(TLC)to predicted value,percentage of forced vital capacity(FVC)to predicted value],laboratory examination indexes[arterial partial pressure of oxygen(PaO_(2)),preprotein,albumin],immune function.Multivariate Logistic regression analysis was used to analyze the influencing factors of poor prognosis in patients with idiopathic pulmonary interstitial fibrosis complicated with malnutrition.Results Among the 50 patients with idiopathic pulmonary fibrosis complicated with malnutrition,35 had good prognosis and 15 had poor prognosis.There were significant differences in age,family income,incidence of dry cough,incidence of chest tightness,number of acute exacerbations,treatment methods,percentage of TLC to predicted value,percentage of FVC to predicted value,PaO_(2),preprotein,albumin and immune function between patients with good prognosis and patients with poor prognosis(P<0.05).Multivariate Logistic regression analysis showed that age≥40 years old,low family income,dry cough,chest tightness,number of acute exacerbations≥1 time per month,surgical treatment,percentage of TLC to predicted value<64%,percentage of FVC to predicted value<70%,PaO_(2)<56 mmHg,preprotein<165 mg/L,albumin<35 g/L,and abnormal immune function were risk factors for poor prognosis in patients with idiopathic pulmonary interstitial fibrosis complicated with malnutrition(P<0.05).Conclusion Age≥40 years old,low family income,dry cough,chest tightness,number of acute exacerbations≥1 time per month,surgical treatment,percentage of TLC to predicted value<64%,percentage of FVC to predicted value<70%,PaO_(2)<56 mmHg,preprotein<165 mg/L,albumin<35 g/L,and abnormal immune function are risk factors for poor prognosis in patients with idiopathic pulmonary interstitial fibrosis complicated with malnutrition.
作者
徐宁宁
尤晓娟
潘磊
田祺
张敏
刘华康
杨丽娜
XU Ningning;YOU Xiaojuan;PAN Lei;TIAN Qi;ZHANG Min;LIU Huakang;YANG Lina(Department of Pulmonary Diseases,Cangzhou Hospital of Integrated TCM-WM·Heibei,Cangzhou 061000,China)
出处
《实用心脑肺血管病杂志》
2024年第10期64-67,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
基金
2021年度河北省医学科学研究课题计划项目(20210344)。
关键词
特发性肺纤维化
营养不良
预后
影响因素分析
Idiopathic pulmonary fibrosis
Malnutrition
Prognosis
Root cause analysis
