摘要
目的基于三叉神经痛中西医病因病机、临床诊断标准以及动物模型的评价指标分析,系统性梳理与总结现有动物模型情况,以期构建吻合度更高的三叉神经痛动物模型。方法通过中国知网和PubMed等数据库,查阅相关三叉神经痛的动物模型文献,对三叉神经痛的中西医病因病机、中西医诊断标准及常见的三叉神经痛动物模型的模型复制对象、模型复制方法、中西医临床表现吻合度进行归纳分析。结果目前应用最为广泛的三叉神经痛动物模型是“眶下神经损伤”手术模型,该模型在病理表现上与三叉神经痛的临床特征具有较高的相似性;其次,“青霉素注射”化学诱导模型在诱发急性疼痛样反应方面表现出显著效果;而光化学诱导模型则能够有效避免手术造模过程中紧致度等因素对实验结果的影响。结论当前中西医结合的造模方法尚处于探索阶段,尚未形成成熟的理论体系。因此,未来应加强开发更多与中医症候证型紧密相关的动物模型,以期为中西医结合治疗三叉神经痛提供更为坚实的理论依据和实验支持。
Objective To construct an animal model with a high consistency of trigeminal neuralgia,this paper systematically reviewed and summarized the existing animal models based on the etiology and pathogenesis analysis of Chinese and western medicine,clinical diagnostic criteria and evaluation indexes of animal models.Methods Literatures on animal models of trigeminal neuralgia were consulted through CNKI and PubMed databases,the etiology and pathogenesis of Chinese and western medicine in the treatment of TN,diagnostic criteria of Chinese and western medicine,model replication objects in common animal models of trigeminal neuralgia,model replication methods and consistency of clinical manifestations of Chinese and western medicine were summarized and analyzed.Results At present,the most widely used model is the“infraorbital nerve injury”surgical model,which has high similarity in pathological manifestations with the clinical features of trigeminal neuralgia.Secondly,the chemical induction model of“penicillin injection”showed significant effect of inducing acute pain-like reactions.The photochemical induction model can effectively avoid the influence of factors such as tightness during surgical modeling process on the experimental results.Conclusion The current modeling method of integrated traditional Chinese and western medicine is still in the stage of exploration and has not formed a mature theoretical system.Therefore,we should actively invest more resources to develop animal models more closely related to traditiona Chinese medicine(TCM)syndromes in future research.The purpose is to provide strong theoretical basis and experimental support for the treatment of trigeminal neuralgia with integrated Chinese and western medicine.
作者
刘雨倩
罗茂丽
朱飞鹏
苗明三
LIU Yuqian;LUO Maoli;ZHU Feipeng;MIAO Mingsan(Henan University of Chinese Medicine,Zhengzhou 450046 Henan,China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2024年第9期1401-1407,共7页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金项目(82274119)
河南省重大专项项目(221100310400)
河南省重大公益专项(201300310100)
岐黄学者(国中医药人教函2022-6)。
关键词
三叉神经痛
病证结合
动物模型
中西医
trigeminal neuralgia
combination of disease and syndrome
animal model
Chinese and western medicine
