摘要
目的:探讨乳腺癌改良根治术联合新辅助化疗对三阴性乳腺癌患者的影响。方法:选取2018年1月—2020年12月莆田市第一医院乳腺甲状腺外科收治的90例三阴性乳腺癌患者。根据随机数表法将其分为对照组和观察组,各45例。对照组给予乳腺癌改良根治术治疗,观察组给予乳腺癌改良根治术联合新辅助化疗。比较两组围手术期指标,术后并发症、健康情况及体力状况,3年随访情况。结果:观察组手术时间、术后住院时间均短于对照组,术中出血量少于对照组,差异有统计学意义(P<0.05)。观察组术后并发症发生率低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组Karnofsky功能状态评分量表(KPS)评分高于对照组,美国东部肿瘤协会组体力状况评分量表(ZPS)评分低于对照组,差异有统计学意义(P<0.05)。观察组局部复发率、远处转移率均低于对照组,3年内生存率高于对照组,差异有统计学意义(P<0.05)。结论:三阴性乳腺癌接受乳腺癌改良根治术联合新辅助化疗,能够获得理想的远期疗效,提升患者生存质量水平,降低疾病复发率。
Objective:To investigate the effect of modified radical mastectomy combined with neoadjuvant chemotherapy on patients with triple-negative breast cancer.Method:A total of 90 patients with triple-negative breast cancer admitted to the Department of Breast and Thyroid Surgery of Putian First Hospital from January 2018 to December 2020 were selected.According to the random numerical table method,they were divided into control group and observation group,45 cases in each group.The control group was given modified radical mastectomy,and the observation group was given modified radical mastectomy combined with neoadjuvant chemotherapy.Perioperative indexes,postoperative complications,health and physical status,and 3-year follow-up condition were compared between the two groups.Result:The operation time and postoperative hospital stay in the observation group were shorter than those in the control group,and the amount of intraoperative blood loss was less than that in the control group,the differences were statistically significant(P<0.05).The incidence of postoperative complications in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).After treatment,the Karnofsky functional status rating scale(KPS)score of the observation group was higher than that of the control group,and the physical status rating scale score of the Eastern American Cancer Society Group(ZPS)was lower than that of the control group,the differences were statistically significant(P<0.05).The local recurrence rate and distant metastasis rate of observation group were lower than control group,and the 3-year survival rate was higher than control group,the differences were statistically significant(P<0.05).Conclusion:Triple negative breast cancer receiving modified radical mastectomy combined with neoadjuvant chemotherapy can obtain ideal long-term efficacy,improve the quality of life of patients and reduce the probability of disease recurrence.
作者
杨欢
郑文添
许东兴
YANG Huan;ZHENG Wentian;XU Dongxing(Putian First Hospital,Putian 351100,China;不详)
出处
《中外医学研究》
2024年第26期118-121,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
改良根治术
新辅助化疗
三阴性乳腺癌
Modified radical mastectomy
Neoadjuvant chemotherapy
Triple negative breast cancer
