摘要
目的:运用数据挖掘技术分析中药专利复方治疗肾病综合征的用药特点与规律,为临床治疗及新药研发提供参考。方法:检索1985年9月10日至2023年11月1日国家知识产权局中国专利公布公告官网(http://epub.cnipa.gov.cn)中治疗肾病综合征的中药专利复方,运用古今医案云平台V2.3.7及SPSS Statistics 26.0软件对符合纳入标准的专利复方进行药物频次和性味归经统计、关联规则分析和系统聚类分析等。结果:共纳入中药专利复方88首,涉及中药249味。药物频次方面,由高至低排序依次为黄芪、白术、泽泻、茯苓和山药等;性味归经方面,四气以平性最多,五味以甘味最多,归经以肝经最多;关联规则方面,置信度由高至低排序依次为白术-黄芪、茯苓-黄芪、泽泻-黄芪等;系统聚类方面,获得的药物组合有熟地黄、山茱萸、山药、芡实、益母草、白茅根与黄芪、党参、甘草等。结论:中药专利复方治疗肾病综合征注重脾肾同调、气血水并治,以健脾补肾、利水渗湿、活血化瘀为基本治法,可为该病的临床治疗及新药研发开拓思路、提供参考。
OBJECTIVE:To analyze the medication characteristics and rules of traditional Chinese medicine patent compound in the treatment of nephrotic syndrome by using data mining technology,so as to provide reference for clinical treatment and new drug development.METHODS:Traditional Chinese medicine patent compound in the treatment of nephrotic syndrome in Announcement of Chinese Patent Publication of China National Intellectual Property Administration(http://epub.cnipa.gov.cn)from Sept.10th,1985 to Nov.1st,2023 were retrieved.The drug frequency,theory of four natures,five flavors and meridian tropism,association rule analysis and systematic cluster analysis of traditional Chinese medicine patent compound that met the inclusion criteria were conducted by using the Ancient And Modern Medical Record Cloud Platform V2.3.7 and SPSS Statistics 26.0 software.RESULTS:A total of 88 kinds of traditional Chinese medicine patent compound were enrolled,including 249 traditional Chinese medicines.In terms of drug frequency,in descending order,Hedysarum multijugum maxim,Atractylodes macrocephala koidz,Alisma orientale(Sam.)juz,Poria cocos(Schw.)wolf,and Rhizoma dioscoreae.In terms of four natures,five flavors and meridian tropism,the four natures were flat,the five flavors were sweet,and the meridian tropism was liver.In terms of association rules,the confidence levels from high to low were Atractylodes macrocephala koidz-Hedysarum multijugum maxim,Poria cocos(Schw.)Wolf-Hedysarum multijugum maxim,Alisma orientale(Sam.)juz-Hedysarum multijugum maxim.In terms of systematic clustering,the obtained drug combinations included Rehmanniae Radix Praeparata,Cornus Officinalis Sieb.Et Zucc,Rhizoma dioscoreae,Euryales semen,Leonuri herba,Imperatae rhizoma and Hedysarum multijugum maxim,Codonopsis Radix,and licorice.CONCLUSIONS:The treatment of nephrotic syndrome by traditional Chinese medicine patent compound focuses on spleen and kidney co-regulation,Qi,blood and water treatment,and takes strengthening the spleen and tonifying the kidney,inducing diuresis and eliminating dampness,activating blood circulation and removing blood stasis as the basic treatment,which can develop ideas and provide references for the clinical treatment of the disease and the research and development of new drugs.
作者
刘江腾
王新宇
李泽宇
王乐
张华
LIU Jiangteng;WANG Xinyu;LI Zeyu;WANG Le;ZHANG Hua(Dept.of Nephrology and Endocrinology,Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 100700,China;Dept.of Traditional Chinese Medicine,Shaoxing People’s Hospital,Zhejiang Shaoxing 312035,China)
出处
《中国医院用药评价与分析》
2024年第9期1030-1034,共5页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
国家中医药管理局第七批全国老中医药专家学术经验继承工作项目(No.202276)。
关键词
肾病综合征
数据挖掘
中药专利复方
用药规律
古今医案云平台
Nephrotic syndrome
Data mining
Traditional Chinese medicine patent compound
Medication rules
Ancient and Modern Medical Record Cloud Platform
