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基于态靶辨证探讨补阳还五汤加减在气虚血瘀型DR中的应用

Exploring the Application of Buyang Huanwu Decoction with Modification Based on the State-targeted Syndrome Differentiation in Qi Deficiency and Blood Stasis Type Dia⁃betic Retinopathy
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摘要 随着生活水平的提高,糖尿病已成为临床上的常见病和多发病。如果未及时治疗,可出现一系列的并发症,其中糖尿病视网膜病变(DR)是其最常见的并发症之一。病理上以视网膜微动脉瘤、出血、渗出、新生血管形成、纤维组织增生为主。现在临床上的治疗方法主要是控制血糖、血压和血脂等危险因素,必要时行手术、药物注射和激光等,尽管疗效肯定,但也存在局限性。中医药在治疗DR方面具有明显优势,但仅凭借传统中医“辨证论治”的方法进行诊治,在无症状患者的治疗中稍显不足。因此,仝小林院士通过大量临床实践,将中医辨证思维和现代医学紧密结合,创立了“态靶因果”辨证方略,在治疗糖尿病及其并发症方面疗效确切。本团队基于其治疗DR的经验,认为本病多以气虚为本,目络瘀阻为标,治疗当以“补气活血通络”为原则,用补阳还五汤调态兼打靶,运用黄连、三七、枸杞子3味中药对眼底视网膜改变精准打靶,临床上疗效确切。 As living standards improve,diabetes has become a common and prevalent disease clinically.If left untreated,it can lead to a series of complications,with diabetic retinopathy(DR)being one of the most common.Pathologically characterized by retinal microaneurysms,hemorrhages,exudates,neovascularization,and fibrous tissue proliferation,the main clinical treatment methods currently focus on controlling risk factors such as blood sugar,blood pressure,and blood lipids,along with surgeries,medication injections,and laser treatments when necessary,albeit with limitations.Traditional Chinese Medicine(TCM)demonstrates significant advantages in treating DR.However,relying solely on the TCM method of"syndrome differentiation and treatment"may be somewhat inadequate in treating asymptomatic patients.Therefore,Academician TONG Xiaolin,through extensive clinical practice,has integrated TCM syndrome differentiation thinking with modern medicine,establishing the"state-target-causality"syndrome differentiation strategy,which has shown definite efficacy in treating diabetes and its complications.Based on their experience in treating DR,the team believes that the disease is mainly rooted in Qi deficiency with blood stasis in the collaterals.Treatment principles emphasize"tonifying Qi,activating blood circulation,and dredging collaterals,"with the use of Buyang Huanwu Decoction to regulate the state while targeting the causative factors.Precise targeting of retinal changes using a combination of Coptis chinensis,Panax notoginseng,and Lycium barbarum has shown definite clinical efficacy.
作者 罗宗秀 陈建业 魏丽娟 LUO Zongxiu;CHEN Jianye;WEI Lijuan(Changchun University of Chinese Medicine,Changchun 130117,China)
出处 《中国中医眼科杂志》 2024年第9期867-872,共6页 China Journal of Chinese Ophthalmology
基金 吉林省自然科学基金(202512JC010477466)。
关键词 态靶辨证 糖尿病性视网膜病变 气虚血瘀 仝小林 syndrome differentiation of state target diabetic retinopathy Qi deficiency and blood stasis TONG Xiaolin
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