摘要
目的:分析生脉散合温胆汤化裁治疗小儿慢性咳嗽的效果。方法:对2022年8月—2023年10月收治的慢性咳嗽患儿118例的临床资料进行回归性分析,根据不同治疗方法分组,应用常规治疗及生脉散合温胆汤化裁治疗的62例患者纳入生脉散合温胆汤组,进行常规治疗的56例患儿纳入常规治疗组,收集两组患儿治疗前后血清炎性因子、免疫球蛋白、T淋巴细胞亚群、疗效、肺功能、不良反应等资料进行统计分析。结果:治疗后血清肿瘤坏死因子-α(TNF-α)、白介素-5(IL-5)水平比较,生脉散合温胆汤组明显低于常规治疗组(P<0.01);治疗后生脉散合温胆汤组血清免疫球蛋白IgG、IgA水平显著高于常规治疗组(P<0.01),IgE水平显著低于常规治疗组(P<0.01);治疗后生脉散合温胆汤组CD4^(+)、CD4^(+)/CD8^(+)显著高于常规治疗组(P<0.01);生脉散合温胆汤组总有效率显著高于常规治疗组(P<0.05);治疗后生脉散合温胆汤组用力肺活量(FVC)及第一秒用力呼气量(FEV_(1))显著高于常规治疗组(P<0.01);治疗期间生脉散合温胆汤组口干、头痛等不良反应总发生率与常规治疗组无显著差异(P>0.05)。结论:应用生脉散合温胆汤化裁治疗小儿慢性咳嗽可抑制患儿炎症反应,改善其体液免疫、细胞免疫、肺功能,提高临床疗效,且中药汤剂安全性高。
Objective:To analyze the efficacy of Shengmai Powder combined with Wendan Decoction in treating chronic cough in children.Methods:A retrospective analysis was conducted on the clinical data of 118 children with chronic cough from August 2022 to October 2023.Patients were divided into two groups based on different treatment methods:62 patients treated with conventional therapy plus Shengmai Powder combined with Wendan Decoction were included in the Shengmai Powder combined with Wendan Decoction group,and 56 patients receiving only conventional treatment were included in the conventional treatment group.Serum inflammatory factors,immunoglobulins,T lymphocyte subgroups,efficacy,pulmonary function,and adverse reactions were collected and statistically analyzed before and after treatment.Results:After treatment,serum levels of tumor necrosis factor-alpha(TNF-α)and interleukin-5(IL-5)were significantly lower in the Shengmai Powder combined with Wendan Decoction group compared to the conventional treatment group(P<0.01).The Shengmai Powder combined with Wendan Decoction group had significantly higher serum levels of immunoglobulin IgG and IgA,and significantly lower IgE levels compared to the conventional treatment group(P<0.01).CD4^(+)and CD4^(+)/CD8^(+)ratios were significantly higher in the Shengmai Powder combined with Wendan Decoction group(P<0.01).The overall effective rate was significantly higher in the Shengmai Powder combined with Wendan Decoction group(P<0.05).Forced vital capacity(FVC)and forced expiratory volume in the first second(FEV1)were significantly higher in the Shengmai Powder combined with Wendan Decoction group compared to the conventional treatment group(P<0.01).The total incidence of adverse reactions such as dry mouth and headache during treatment showed no significant difference between the two groups(P>0.05).Conclusion:Shengmai Powder combined with Wendan Decoction is effective in reducing inflammation,improving both humoral and cellular immunity,and enhancing pulmonary function in children with chronic cough.It also significantly improves clinical outcomes with high safety of the traditional Chinese medicine decoction.
作者
张萍萍
韩一恒
李伟伟
ZHANG Pingping;HAN Yiheng;LI Weiwei(Department of Traditional Chinese Medicine,Lianyungang First People's Hospital,Lianyungang 222000,China;Nanjing University of Chinese Medicine,Nanjing 210023,China;Department of Pediatrics,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China)
出处
《中医药学报》
CAS
2024年第10期67-71,共5页
Acta Chinese Medicine and Pharmacology
基金
2021年广西名中医工作室建设项目(2021022-001-08)。
关键词
生脉散合温胆汤
小儿慢性咳嗽
免疫力
炎性因子
回顾性分析
Shengmai Powder combined with Wendan Decoction
Chronic cough in children
Immunity
Inflammatory factors
Retrospective analysis
